{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T02:42:24Z","timestamp":1761619344861},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":7637,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Photodynamic therapy (PDT) utilizing hematoporphyrin derivative (Hpd) as photosensitizer and an argon\u2010dye laser as the light source was used alone and in combination with a localized microwave hyperthermia treatment to treat the SMTF mammary carcinoma in mice. A 30\u2010min heat treatment at 44.5\u00b0C was applied 0\u20138 hr before or after a standard photodynamic treatment (67.5 or 135 J\/cm<jats:sup>2<\/jats:sup>, given 24 hr post\u20107.5 mg\/kg Hpd). Potentiation of PDT by heat was found to be related to the sequence of the treatments and the time interval between them.<\/jats:p><jats:p>When 44.5\u00b0C for 30 min was applied immediately after a 15\u2010min PDT treatment, significant potentiation was seen (58% long\u2010term tumor control vs 3 and 10%, respectively, for PDT and heat alone). This potentiation decreased with increasing time between PDT and heat, with tumor control values decreasing to 36, 20, and 14%, when 2, 4, and 8 hr, respectively, were allowed between treatments. Only additive effects of the independent therapies were found when this heat treatment was applied 0\u20138 hr before PDT.<\/jats:p><jats:p>In other experiments, mice were treated with single or fractionated 30\u2010min PDT treatments (two 15\u2010min treatments separated by 0\u2010,\u20102\u2010, 4\u2010, or 8\u2010hr intervals). Decreases in tumor control were seen with increasing time interval; only minor differences in tumor control were seen when 4\u20138 hr was allowed between treatments compared to a single 15\u2010min treatment.<\/jats:p>","DOI":"10.1002\/lsm.1900050203","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T01:18:54Z","timestamp":1172884734000},"page":"83-94","source":"Crossref","is-referenced-by-count":72,"title":["Potentiation of photodynamic therapy by heat: Effect of sequence and time interval between treatments in vivo"],"prefix":"10.1002","volume":"5","author":[{"given":"Stephen M.","family":"Waldow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara W.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Dougherty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Critical Reviews in Oncology\u2010Hematology","author":"Dougherty TJ","year":"1985"},{"key":"e_1_2_1_3_2","first-page":"430","article-title":"Laser photoradiation therapy of cancer","volume":"43","author":"Dahlman A","year":"1983","journal-title":"Cancer Res"},{"key":"e_1_2_1_4_2","first-page":"1836","volume-title":"Cancer: Principles and Practice of Oncology.","author":"Dougherty TJ","year":"1982"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-4193-2"},{"key":"e_1_2_1_6_2","first-page":"2264","article-title":"Potential for therapy of drugs and hyperthermia","volume":"39","author":"Hahn GM","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/116.2.433"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1148\/123.2.463"},{"key":"e_1_2_1_9_2","first-page":"2290","article-title":"Potential for hyperthermia and radiation therapy","volume":"39","author":"Suit HD","year":"1979","journal-title":"Cancer Res"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-53-628-346"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.2307\/3576288"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900040111"},{"key":"e_1_2_1_13_2","first-page":"39","article-title":"Study of fast (F) and slow (S) growing transplantable tumors derived from spontaneous mammary tumors (SMT) of the DBA\u20102Ha\u2010DD mouse","volume":"14","author":"Hosokawa M","year":"1973","journal-title":"Proc Am Assoc Can Res [Abstract]"},{"key":"e_1_2_1_14_2","first-page":"2657","article-title":"Fast\u2010 and slow\u2010growing transplantable tumors from spontaneous mammary tumors of the DBA\u20102Ha\u2010DD mouse","volume":"35","author":"Hosokawa M","year":"1975","journal-title":"Cancer Res"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-4406-3_8"},{"key":"e_1_2_1_16_2","unstructured":"MangTS DoughertyTJ:The effect of hyperthermia on the in vitro survival of cells exposed to photodynamic therapy. Photochem Photobiol (submitted)."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1984.142"},{"key":"e_1_2_1_18_2","unstructured":"HendersonBW WaldowSM PotterWR MalonePB DoughertyTJ:Tumor destruction and kinetics of tumor cell death in two experimental mouse tumors following photodynamic therapy. Cancer Res in press 1985."},{"key":"e_1_2_1_19_2","volume-title":"Effect of variables on PDT","author":"Dougherty TJ","year":"1984"},{"key":"e_1_2_1_20_2","unstructured":"MarchesiniR ZuninoF EmanuelliH MelloniE PezzoniG LocatiL FavaG:Hyperthermal effect in Hpd phototherapy. Salt Lake City UT: Fourth Annual Meeting of the American Society for Laser Medicine and Surgery [Abstract] June 1984."},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1118\/1.595373"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.1900050203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.1900050203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T18:11:54Z","timestamp":1697825514000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.1900050203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,1]]}},"alternative-id":["10.1002\/lsm.1900050203"],"URL":"https:\/\/doi.org\/10.1002\/lsm.1900050203","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}