{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:48:07Z","timestamp":1787680087840,"version":"build-2784847793"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T00:00:00Z","timestamp":1133222400000},"content-version":"vor","delay-in-days":7637,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Five patients with various gynecologic neoplasms were treated with photodynamic therapy using 630\u2010nm light delivered from an argon dye laser system following the intravenous injection of hematoporphyrin derivative (HpD). A patient with multifocal squamous cell cancer of the vagina had no evidence of disease 15 months after her first photodynamic therapy treatment. Autopsy nine months after the first treatment of another patient with multifocal invasive cancer of the vagina and parametrium showed no evidence of tumor on the surface of the vagina. Eight months after treatment of an 8 \u00d7 12 cm area of Bowen's disease of the vulva and thigh, there was no evidence of disease. Vaginal bleeding from breast cancer metastatic to the endometrium was controlled by one treatment until the patient expired five months later from her disease. Adenocarcinoma metastatic to the vaginal cuff showed partial response when vaginectomy was performed five weeks after photodynamic therapy.<\/jats:p>","DOI":"10.1002\/lsm.1900050508","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T08:18:16Z","timestamp":1172909896000},"page":"491-498","source":"Crossref","is-referenced-by-count":33,"title":["Photodynamic therapy of gynecologic neoplasms after presensitization with hematoporphyrin derivative"],"prefix":"10.1002","volume":"5","author":[{"suffix":"Jr.","given":"James S.","family":"McCaughan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut F.","family":"Schellhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Lomano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley H.","family":"Bethel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900040108"},{"key":"e_1_2_1_3_2","first-page":"2628","article-title":"Photoradiation therapy for the treatment of malignant tumors","volume":"38","author":"Dougherty TJ","year":"1978","journal-title":"Cancer Res"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-38270-6_7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-4406-3_7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2530\/jslsm1980.4.1_85","article-title":"Experimental studies of photoradiation therapy (PRT) against human uterine cancer cell line","volume":"4","author":"Kubota K","year":"1983","journal-title":"J Jpn Soc Laser Med"},{"key":"e_1_2_1_7_2","first-page":"78","article-title":"Hematoporphyrin derivative for the detection of cervical cancer","volume":"24","author":"Lipson RL","year":"1964","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900030302"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19841215)54:12<2905::AID-CNCR2820541215>3.0.CO;2-N"},{"key":"e_1_2_1_10_2","first-page":"767","volume-title":"Porphyrin Localization and Treatment of Tumors.","author":"Rettenmaier MA","year":"1984"},{"key":"e_1_2_1_11_2","first-page":"97","volume-title":"Lasers And Hematoporphyrin Derivative in Cancer.","author":"Soma H","year":"1983"},{"key":"e_1_2_1_12_2","first-page":"88","volume-title":"Lasers and Hematoporphyrin Derivative in Cancer.","author":"Tokuda Y","year":"1983"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(82)90744-X"},{"key":"e_1_2_1_14_2","first-page":"2326","article-title":"Identification of singlet oxygen as the cytotoxic agent in photo\u2010inactivation of a murine tumor","volume":"36","author":"Weishaupt KR","year":"1976","journal-title":"Cancer Res"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.1900050508","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.1900050508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T13:24:22Z","timestamp":1697808262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.1900050508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1985,1]]}},"alternative-id":["10.1002\/lsm.1900050508"],"URL":"https:\/\/doi.org\/10.1002\/lsm.1900050508","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}