{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:13:17Z","timestamp":1760908397084},"reference-count":6,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T00:00:00Z","timestamp":1129680000000},"content-version":"vor","delay-in-days":7231,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A significant number of patients with ischemic heart disease are not candidates for coronary artery bypass or percutaneous transluminal angioplasty and do not respond to medical management. This group includes those who have diffuse coronary artery disease, those with poor ventricular function, and those who have had poor results from previous surgery.<\/jats:p><jats:p>Developing a method to directly revascularize the myocardium by creating channels through the ventricular wall has challenged many investigators. Early methods, including needle acupuncture, were successful in the acute phase, but long\u2010term patency could not be achieved. Closure of the channels was due to fibrosis and scarring.<\/jats:p><jats:p>Experiments in our laboratory demonstrated that myocardial channels, made with the CO<jats:sub>2<\/jats:sub> laser, remained patent up to five years. Histopathologic examination of the channels showed minimal damage to the surrounding cells in the acute phase. Studies at intervals of two months to two years showed patent endothelialized channels, with no evidence of fibrosis. Channels created in the myocardium protected the ventricle against an ischemic event when the left anterior descending branch of the coronary artery was ligated.<\/jats:p><jats:p>Clinical experience with direct myocardial revascularization by CO<jats:sub>2<\/jats:sub> laser indicates it may be a viable method of treating those patients with ischemic heart disease who are not candidates for other forms of management. The treatment and early postoperative follow\u2010up in one patient are described.<\/jats:p>","DOI":"10.1002\/lsm.1900060507","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T09:54:41Z","timestamp":1172915681000},"page":"459-461","source":"Crossref","is-referenced-by-count":65,"title":["Clinical report: Laser myocardial revascularization"],"prefix":"10.1002","volume":"6","author":[{"given":"Mahmood","family":"Mirhoseini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary M.","family":"Cayton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhas","family":"Shelgikar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"257","article-title":"Myocardial revascularization by a new method of carrying blood directly from the left vetnricular cavity into coronary circulation","volume":"34","author":"Massimo C","year":"1957","journal-title":"J Thorac Cardiovas Surg"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900030307"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.1920020406"},{"key":"e_1_2_1_5_1","first-page":"181","article-title":"Transmyocardial acupuncture","volume":"50","author":"Sen PK","year":"1965","journal-title":"J Thorac Cardiovas Surg"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000127559"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(33)90711-5"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.1900060507","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.1900060507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T09:38:18Z","timestamp":1697881098000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.1900060507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":6,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1986,1]]}},"alternative-id":["10.1002\/lsm.1900060507"],"URL":"https:\/\/doi.org\/10.1002\/lsm.1900060507","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}