{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:35:48Z","timestamp":1700181348939},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":6531,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although laser is effective in the treatment of genital condylomata, patients with extensive lesions frequently require more than one treatment. The present study was undertaken to investigate whether the cure rate achieved by a single laser treatment could be improved by adding topical 5% 5\u2010fluorouracil (5\u2010FU). Twenty patients with extensive genital condylomata were treated with laser alone. Twenty patients comparable to the first group in age, number, size, and distribution of the condylomata were treated by laser and 5\u2010FU. The first application of 5% 5\u2010FU cream was carried out at the end of the laser treatment by the surgeon in the operating room. The patients were instructed to apply 5\u2010FU cream once weekly to the vulva and once every two weeks to the vagina by using an applicator filled to one\u2010third with 5\u2010FU cream. Seven patients (35%) without 5\u2010FU were found to have persistent condylomata at the first follow\u2010up examination eight to 12 weeks after the single laser treatment. Two additional patients were noted to have disease six and nine months after laser treatment. The combination of laser and 5\u2010FU failed in two cases (10%), both identified at the first visit. The difference is statistically significant (<jats:italic>P<\/jats:italic> &lt;.025, chi\u2010square test). Two patients exposed to 5\u2010FU experienced chemical vulvitis. It is concluded that the combination of a single laser treatment and 5\u2010FU has acceptable side effects and results in a higher cure rate than a single laser treatment without 5\u2010FU.<\/jats:p>","DOI":"10.1002\/lsm.1900080208","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T01:55:08Z","timestamp":1172886908000},"page":"135-138","source":"Crossref","is-referenced-by-count":10,"title":["Combination of laser plus 5\u2010fluorouracil for the treatment of extensive genital condylomata acuminata"],"prefix":"10.1002","volume":"8","author":[{"given":"Hans\u2010B.","family":"Krebs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"737","article-title":"Treating viral venereal infections with the CO2 laser","volume":"27","author":"Baggish MA","year":"1982","journal-title":"J Reprod Med"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90470-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)32228-1"},{"key":"e_1_2_1_5_1","first-page":"105","article-title":"Management of condylomata acuminata with carbon dioxide laser","volume":"59","author":"Calkins JW","year":"1982","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590210005001"},{"key":"e_1_2_1_7_1","first-page":"773","article-title":"Comparison of 5\u2010fluorouracil and CO2 laser for treatment of vaginal condylomata","volume":"64","author":"Ferenczy A","year":"1984","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198509263131304"},{"key":"e_1_2_1_9_1","first-page":"466","article-title":"Treatment of condylomata acuminata with 5% 5\u2010fluorouracil (5\u2010FU) cream","volume":"50","author":"Haye KR","year":"1974","journal-title":"Br J Vener Dis"},{"key":"e_1_2_1_10_1","first-page":"837","article-title":"Prophylactic topical 5\u2010fluorouracil following treatment of human papillomavirus\u2010associated lesions of the vulva and vagina","volume":"68","author":"Krebs HB","year":"1986","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_11_1","first-page":"67","article-title":"The treatment of vaginal condylomata acuminata by weekly topical application of 5\u2010fluorouracil","volume":"70","author":"Krebs HB","year":"1987","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_12_1","first-page":"489","article-title":"The CO2 laser for recurrent and therapy\u2010resistant condylomata acuminata","volume":"30","author":"Krebs HB","year":"1985","journal-title":"J Reprod Med"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348409155528"},{"key":"e_1_2_1_14_1","unstructured":"VC RiopelleMA: \u201cGynecologic Laser Surgery: A Practical Handbook.\u201d Biomedical Communications 1983p131."}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.1900080208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.1900080208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T09:34:54Z","timestamp":1697967294000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.1900080208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.1002\/lsm.1900080208"],"URL":"https:\/\/doi.org\/10.1002\/lsm.1900080208","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]}}}