{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T05:10:21Z","timestamp":1695877821535},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":6531,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Normal urethral response to photodynamic therapy (PDT) utilizing a cylindrical fiber was assessed in ten study and two control NIH foxhounds. The canine urethras were treated 48 hours after intravenous injection of 3 mg\/kg dihematoporphyrin ether (Photofrin II). A 1\u2010mm fused silica optical fiber, with the distal 2\u20133 cm modified for cylindrical light distribution (660\u2010\u03bcm diameter), was placed in the pendulous urethra. An argon\u2010pumped dye laser delivered 100 mW of 630\u2010nm light for 7 minutes (42 J) to the treatment area. Urethroscopy using either a 2.5\u2010mm or a 2.8\u2010mm flexible pediatric bronchoscope with video recording capability was performed immediately after PDT (12 animals) and 6 weeks later (nine animals); intravenous urography was performed 3 days and 6 weeks after PDT. There was no evidence of either urethral damage or stricture formation in any animal. Histopathology of the first three study specimens, obtained at 6 weeks, confirmed the absence of any pathology. Flexible instrumentation facilitates post\u2010treatment assessment. This study demonstrates for the first time that, when a cylindrical fiber is used, photodynamic therapy may be applied to the urethra without damage to the normal urethral mucosa. This result has implications for potential treatment of initial or recurrent carcinoma in situ of the urethra using PDT.<\/jats:p>","DOI":"10.1002\/lsm.1900080313","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T10:43:29Z","timestamp":1172918609000},"page":"301-307","source":"Crossref","is-referenced-by-count":3,"title":["Photodynamic therapy: Response of normal canine urethra using a cylindrical fiber"],"prefix":"10.1002","volume":"8","author":[{"given":"Michael J.","family":"Manyak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna M.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucien 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