{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:16:01Z","timestamp":1760897761048},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T00:00:00Z","timestamp":1129680000000},"content-version":"vor","delay-in-days":6135,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Laser\u2010induced fluorescence (LIF) spectroscopy can only be used for laser angioplasty guidance if high\u2010power laser ablation does not significantly alter the pattern of tissue fluorescence. Although the spectra of normal and atherosclerotic arteries differ, the change in fluorescence spectra following laser angioplasty has not been well studied. Therefore, the purpose of this study was to assess whether laser\u2010induced fluorescence spectroscopy could guide selective laser ablation of atherosclerotic plaque and, if so, to develop a quantitative LIF score that could be used to control a \u201csmart\u201d laser angioplasty system.<\/jats:p><jats:p>Baseline LIF spectroscopy of 50 normal and 50 atherosclerotic human aortic specimens was performed using an optical fiber coupled to a He\u2010Cd laser and optical multichannel analyzer. LIF was then serially recorded during erbium:YAG laser ablation of 27 atherosclerotic specimens. Laser ablation was terminated when the arterial LIF spectrum visually appeared normal. Histologic analysis revealed a mean initial plaque thickness of 1,228 \u00b1 54 \u03bcm and mean residual plaque thickness of 198 \u00b1 27 \u03bcm. Ablation of the media occurred in only three specimens.<\/jats:p><jats:p>A discriminant function was derived to discriminate atherosclerotic from normal tissue for computer guidance of laser angioplasty. The LIF score, derived from stepwise multivariate linear regression analysis of the LIF spectra, correctly classified 93% of aortic specimens. The spectra obtained from the atherosclerotic specimens subjected to fluorescence\u2010guided laser revealed a change in score from \u201catherosclerotic\u201d to \u201cnormal\u201d following plaque ablation. Seven atherosclerotic specimens were subjected to laser angioplasty with on\u2010line computer control using the LIF score. Mean initial plaque thickness was 1,014 \u00b1 86 \u03bcm, and mean residual plaque thickness was 78 \u00b1 29 \u03bcm. There was no evidence of ablation of the media. Therefore, LIF guidance of laser ablation resulted in minimal residual plaque without arterial perforation. These findings support the feasibility of an LIF\u2010guided laser angioplasty system for selective atherosclerotic plaque ablation.<\/jats:p>","DOI":"10.1002\/lsm.1900090303","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T11:02:56Z","timestamp":1172919776000},"page":"205-214","source":"Crossref","is-referenced-by-count":50,"title":["Fluorescence spectroscopy guidance of laser ablation of atherosclerotic plaque"],"prefix":"10.1002","volume":"9","author":[{"given":"Lawrence I.","family":"Deckelbaum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark L.","family":"Stetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken M.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis 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