{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T02:42:24Z","timestamp":1761619344781},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,2]],"date-time":"2005-12-02T00:00:00Z","timestamp":1133481600000},"content-version":"vor","delay-in-days":5449,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Six patients with an early stage of gastrointestinal (GI) cancer (T<jats:sub>1<\/jats:sub>N<jats:sub>o<\/jats:sub>M<jats:sub>o<\/jats:sub>, stage I) were successfully treated by photodynamic therapy (PDT) as follows: esophagus\u20101, stomach\u20102, rectum\u20103. The patients were photosensitized 72 hrs prior to treatment with pure hematoporphyrin at a dose of 5.10<jats:sup>\u22126<\/jats:sup> kg\/kg b.w. in a slow intravenous infusion. Argon\u2010pumped dye laser light at 0.630 \u03bcm wave\u2010length was used in single and multiple treatment sessions with the power density ranging from 0.015 to 0.192 W.m<jats:sup>\u22122<\/jats:sup> and a dose varying from 0.320 to 1.600 kJ.m<jats:sup>\u22122<\/jats:sup>. Tumor eradication (complete response) was obtained in each of the patients. No early or late treatment related complications were recorded. The patients were followed\u2010up in the course of 7\u201316 months after treatment and no local recurrence or general development of disease (metastases) were reported. PDT in the early stage of GI carcinoma was recognized as a radical therapeutic method in clinical oncology.<\/jats:p>","DOI":"10.1002\/lsm.1900110502","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T13:36:21Z","timestamp":1172928981000},"page":"395-398","source":"Crossref","is-referenced-by-count":19,"title":["Photodynamic therapy in gastrointestinal cancer"],"prefix":"10.1002","volume":"11","author":[{"given":"Strashimir","family":"Karanov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Shopova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hristo","family":"Getov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,2]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"19","article-title":"Application of laser in cancer diagnosis and treatment","volume":"14","author":"Hayata Y","year":"1982","journal-title":"Med Imag Inform"},{"key":"e_1_2_1_3_2","first-page":"298","article-title":"Endoscopic photodynamic therapy of stomach and colon tumors","volume":"28","author":"Ito Y","year":"1986","journal-title":"Gastroenterol Endoscopy"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1989.01410010084018"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860201)57:3<677::AID-CNCR2820570347>3.0.CO;2-V"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198708000-00012"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02594131"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02032433"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ssu.2980010103"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02032460"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.1900110502","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.1900110502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T23:55:59Z","timestamp":1698018959000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.1900110502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.1002\/lsm.1900110502"],"URL":"https:\/\/doi.org\/10.1002\/lsm.1900110502","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}