{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:16:00Z","timestamp":1760897760188},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,12,2]],"date-time":"2005-12-02T00:00:00Z","timestamp":1133481600000},"content-version":"vor","delay-in-days":5449,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to examine the effects of photodynamic therapy utilizing aluminum phthalocyanine tetrasulfonate in vitro on several human malignant and normal cell types, with or without hyperthermia. Cells examined included normal skin fibroblasts, HT\u20101080 fibrosarcoma cells, SCC\u201025 (squamous cell carcinoma) and malignant melanoma cells. An argon\u2010pumped continuous wave tunable dye laser at 675 nm was used as the light source, hyperthermia groups were heated to 42.5\u00b0C, and radioisotope incorporation was used to measure DNA and protein synthesis as toxicity assays. Results showed an energy\u2010dose, and AlPcS\u2010concentration dependent toxicity in all cell lines examined, with moderate selectivity toward malignant cells. Hyperthermia lone was slightly toxic in melanomas and HT\u20101080 cell lines but had no effect in normal fibroblasts or SCC\u201025 cells. Hyperthermia synergistically potentiated the effects of PDT in all cell lines, and the combined modality was significantly more toxic in all malignant cell lines compared with normal cells. Thus, addition of hyperthermia to PDT protocols may enhance the efficacy of this treatment modality in vitro.<\/jats:p>","DOI":"10.1002\/lsm.1900110508","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T13:36:21Z","timestamp":1172928981000},"page":"432-439","source":"Crossref","is-referenced-by-count":12,"title":["Hyperthermia potentiates the effects of aluminum phthalocyanine tetrasulfonate\u2010mediated photodynamic toxicity in human malignant and normal cell lines"],"prefix":"10.1002","volume":"11","author":[{"given":"Edward","family":"Glassberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Lewandowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Halcin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Lask","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jouni","family":"Uitto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-2165-1_30"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900060113"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)92596-2"},{"key":"e_1_2_1_5_2","first-page":"15","article-title":"Phthalocyanines 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