{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:33:42Z","timestamp":1760888022655},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T00:00:00Z","timestamp":1129680000000},"content-version":"vor","delay-in-days":5040,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The potential advantages of CO<jats:sub>2<\/jats:sub> laser in apical surgery have not been established histologically. Therefore, the long\u2010term effects of CO<jats:sub>2<\/jats:sub> laser on the apical and periapical tissues were examined histologically in dogs 6 months after apical surgery. Lased specimens and unlased controls showed periapical inflammatory and osteogenic reactions. Lased root surfaces revealed craters with a superficial charred layer closely associated with new cementum\u2010like matrix. The subjacent dentin appeared tubule\u2010free and eosinophylic. Lased bone trabeculae showed a charred layer with a deeper osteocyte\u2010free zone. The charred layer was covered by new bone. Detached charred segments in the marrow space and periapical inflammatory infiltrate were intimately associated with multinucleated giant cells, some containing minute char particles. Such cells were absent from the root and trabecular char linings. In addition, the charred surfaces were free of hard tissue resorption. These results suggest that CO<jats:sub>2<\/jats:sub> laser does not hinder healing when applied in apical surgery.<\/jats:p>","DOI":"10.1002\/lsm.1900120116","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T13:52:52Z","timestamp":1172929972000},"page":"104-111","source":"Crossref","is-referenced-by-count":10,"title":["Tissue response following CO<sub>2<\/sub> laser application in apical surgery: Light microscopic assessment in dogs"],"prefix":"10.1002","volume":"12","author":[{"given":"Shimon","family":"Friedman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan","family":"Rotstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itai","family":"Bab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,19]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"575","volume-title":"Pathways of the Pulp","author":"Arens DE","year":"1991"},{"key":"e_1_2_1_3_2","first-page":"326","volume-title":"Endodontology. Biologic Considerations in Endodontic Procedures","author":"Seltzer S","year":"1988"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1985.tb00512.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1990.tb00394.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1991.tb00192.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1989.tb00922.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9785(79)80016-2"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(07)80158-0"},{"key":"e_1_2_1_10_2","unstructured":"MelcerF MelcerJ DejardinJ LancretJ GautierJ.Short\u2010 and middle\u2010term results in human dentistry after CO2 laser beam exposition. In: Atsumi K Nimsakul N eds. Proceedings of the Fourth Congress of the International Society for Laser Surgery Tokyo Japan 1981; session 12:1\u20134."},{"key":"e_1_2_1_11_2","first-page":"225","volume-title":"New Frontiers in Laser Medicine and Surgery","author":"Melcer J","year":"1983"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900060409"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(88)90385-4"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1139\/m86-174"},{"key":"e_1_2_1_15_2","first-page":"148","article-title":"In vitro sterilization of dental caries by CO2 laser irradiation","volume":"8","author":"Miserendino LJ","year":"1988","journal-title":"Lasers Surg Med"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016357309002525"},{"key":"e_1_2_1_17_2","first-page":"74","article-title":"Laser irradiation of human dental enamel and dentine","volume":"82","author":"Nelson DGA","year":"1986","journal-title":"NZ Dent J"},{"key":"e_1_2_1_18_2","first-page":"932","article-title":"Healing of continuous\u2010wave and rapid superpulsed carbon dioxide laser\u2010induced bone defects","volume":"36","author":"Clayman L","year":"1978","journal-title":"J Oral Maxillofac Surg"},{"key":"e_1_2_1_19_2","first-page":"159","article-title":"Observations of carbon dioxide laser and bone bur in the osteotomy of the rabbit tibia","volume":"37","author":"Small IA","year":"1979","journal-title":"J Oral Surg"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453677908989780"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900110112"},{"key":"e_1_2_1_22_2","unstructured":"BarahonaJF HashimotoK KawaguchiT FukudaH MizukiH.The experimental study of the effects of CO2laser in periodontal tissues in dogs. In: Atsumi K Nimsakul N eds. \u201cProceedings of the Fourth Congress of the International Society for Laser Surgery \u201d Tokyo Japan 1981; session 12:9\u201312."},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0266-4356(84)90048-2"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1991.tb00178.x"},{"key":"e_1_2_1_25_2","first-page":"27","article-title":"The microscopic appearance of the periapical tissue in cases classified as \u201cuncertain\u201d or \u201cunsuccessful\u201d affter apicoectomy","volume":"25","author":"Arwill T","year":"1974","journal-title":"Odont Rev"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00494644"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201241"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900080204"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.1900120116","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.1900120116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T21:22:35Z","timestamp":1698096155000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.1900120116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1002\/lsm.1900120116"],"URL":"https:\/\/doi.org\/10.1002\/lsm.1900120116","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}