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This pulse energy is nearly two orders of magnitude less than the typical pulse energies used in conventional (nanosecond) photodisruptors. The reduced pulse energy results in a smaller zone of tissue damage, an important consideration when operating close to the retina or other sensitive ocular structures. Efficient cutting action is achieved by applying multiple pulses at a moderately high repetition rate of 50\u2013200 Hz. An in vitro model was developed to assess axial confinement of picosecond photodisruption. In vivo vitreous membrane surgery was performed in experimental rabbit eyes to demonstrate a potential clinical application of picosecond laser\u2014induced optical breakdown. \u00a9 1994 Wiley\u2010Liss, inc.<\/jats:p>","DOI":"10.1002\/lsm.1900150107","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T16:28:59Z","timestamp":1172939339000},"page":"44-53","source":"Crossref","is-referenced-by-count":12,"title":["Intraocular microsurgery with a picosecond Nd:YAG laser"],"prefix":"10.1002","volume":"15","author":[{"given":"Charles P.","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaffa K.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reginald","family":"Birngruber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G.","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen A.","family":"Puliafito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,2]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"192","article-title":"Q\u2010switched laser iridectomy and Q\u2010switched laser goniopuncture","volume":"34","author":"Krasnov MM","year":"1977","journal-title":"Adv Ophthalmol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00130696"},{"key":"e_1_2_1_4_2","first-page":"496","article-title":"Use of a pulsed neodymium YAG laser (picosecond) to open the posterior lens capsul in traumatic cateract; 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