{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:50:42Z","timestamp":1790715042940,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T00:00:00Z","timestamp":1129680000000},"content-version":"vor","delay-in-days":3944,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background and Objective:<\/jats:italic> Photodynamic therapy (PDT) has been used successfully to occlude neovascularizations experimentally. We evaluated the vasoocclusive potential of benzoporphyrin derivative (BPD), a new photosensitizer currently in clinical trials. Since liposomally formulated BPD strongly binds to endogenous low density lipoproteins (LDL) after i.v. injection, LDL act as carrier to deliver BPD preferentially to proliferating endothelial cells.<\/jats:p><jats:p><jats:italic>Study Design\/Materials and Methods:<\/jats:italic> Corneal neovascularizations in rabbits were used as model. Time\u2010dependent uptake and retention of liposomal BPD were measured in vivo by monitoring the laser\u2010induced fluorescence (LIF). Photothrombosis was induced using a dye laser emitting at 692 nm.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> A maximal BPD concentration was measured at 60\u201390 minutes postinjection determining the optimal time interval for treatment. Exposures as low as 10 J\/cm<jats:sup>2<\/jats:sup> allowed complete and irreversible neovascular occlusion as documented angiographically. Histology revealed selective endothelial damage, adjacent corneal stroma, or iris vessels, remained intact. Identical results were obtained using BPD directly complexed with LDL suggesting use of a LDL\u2010mediated pathway.<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic> We suggest BPD\u2010PDT for a selective treatment of neovascular diseases. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/lsm.1900170207","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T17:18:24Z","timestamp":1172942304000},"page":"178-188","source":"Crossref","is-referenced-by-count":63,"title":["In vivo uptake of liposomal benzoporphyrin derivative and photothrombosis in experimental corneal neovascularization"],"prefix":"10.1002","volume":"17","author":[{"given":"Ursula","family":"Schmidt\u2010Erfurth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayyaba","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Schomacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Flotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reginald","family":"Birngruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1984.01040030398010"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113629"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1987.tb04854.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1984.01040030971028"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1987.tb04863.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1988.01060130742036"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1989.01070020575043"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1987.01060070127041"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1987.01060080123041"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1988.01060140776054"},{"key":"e_1_2_1_12_2","first-page":"2357","article-title":"Photodynamic retinal vascular occlusion","volume":"32","author":"Wilson CA","year":"1991","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090060145039"},{"key":"e_1_2_1_14_2","unstructured":"KlimanGH SternD GregoryWA BovirakS PuliafitoCA.Angiography and photodynamic therapy of experimental choroidal neovascularization using phthalocyanine dye. 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