{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T18:00:43Z","timestamp":1759514443745},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,12,20]],"date-time":"2004-12-20T00:00:00Z","timestamp":1103500800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Third molars (wisdom teeth) in humans have limited functional value and cause a high frequency of morbidity. A window of opportunity exists to stop their development. The purpose of this study is to evaluate whether a long pulse diode laser can selectively prevent third molar development in a rat animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>The study calculated theoretical diode laser parameters and irradiated 2\u2010 to 4\u2010day\u2010old rat pups in the posterior aspects of the oral cavity near the time of tooth bud initiation. Rats were sacrificed at 35\u201350 days and examined intraorally and radiographically for third molar development. Control and treated sides were compared histologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nearly half of the maxillary third molars and 80% of the mandibular third molars were selectively prevented from developing using a 20 W diode laser with infrequent, minor adverse effects on maxillary jaw growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study confirms the hypothesis that controlled, non\u2010invasive laser treatment delivered on the surface of the oral mucosa near the site of tooth bud formation can selectively achieve third molar agenesis. It also offers hope that further innovative studies may bring about a safe, non\u2010invasive laser treatment to selectively prevent third molar development in humans. Lasers Surg. Med. 35:385\u2013391, 2004. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.20093","type":"journal-article","created":{"date-parts":[[2004,12,20]],"date-time":"2004-12-20T22:58:13Z","timestamp":1103583493000},"page":"385-391","source":"Crossref","is-referenced-by-count":3,"title":["Prevention of third molar tooth development in neonate rat with a long pulse diode laser"],"prefix":"10.1002","volume":"35","author":[{"suffix":"Jr.","given":"Anthony R.","family":"Silvestri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirko G.","family":"Mirkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond J.","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2003.0194"},{"key":"e_1_2_1_3_2","first-page":"95","volume-title":"Oral histology: Development, structure, and function","author":"Ten Cate AR","year":"1998"},{"key":"e_1_2_1_4_2","first-page":"24","volume-title":"Orban's oral histology and embryology","author":"Bhaskar SN","year":"1986"},{"key":"e_1_2_1_5_2","first-page":"284","volume-title":"Development of the human dentition: An atlas","author":"Van der Linden FPGM","year":"1976"},{"key":"e_1_2_1_6_2","first-page":"75","article-title":"Evolutions: Mammalian tooth development","volume":"9","author":"Lewin D","year":"1997","journal-title":"J NIH Res"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(71)90065-X"},{"key":"e_1_2_1_8_2","first-page":"235","article-title":"The effects of local hyperthermia on odontogenesis","volume":"37","author":"Gordon NC","year":"1979","journal-title":"J Oral Surg"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2004.0049"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1242\/dev.103.Supplement.213","article-title":"Teratogens and craniofacial malformations: Relationship to cell death","volume":"103","author":"Sulik KK","year":"1988","journal-title":"Development"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00305754"},{"key":"e_1_2_1_12_2","first-page":"190","volume-title":"Dental and oral tissues","author":"Moss\u2010Salentijn L","year":"1980"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1242\/dev.109.2.461","article-title":"Multiple functions for NGF receptor in developing, aging, and injured rat teeth are suggested by epithelial, mesenchymal and neural immunoreactivity","volume":"109","author":"Byers MR","year":"1990","journal-title":"Development"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000141470"},{"key":"e_1_2_1_15_2","first-page":"275","volume-title":"Optical\u2010thermal response of laser\u2010irradiated tissue","author":"Cheong W","year":"1995"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-2607(95)01640-F"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-2607(97)00021-7"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711080105"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.20093","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.20093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T15:04:28Z","timestamp":1700233468000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.20093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1002\/lsm.20093"],"URL":"https:\/\/doi.org\/10.1002\/lsm.20093","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}