{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:38:10Z","timestamp":1790937490809,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,4,26]],"date-time":"2005-04-26T00:00:00Z","timestamp":1114473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Photodynamic therapy (PDT) mediated with Tookad (Pd\u2010bacteriopheophorbide, WST09) was investigated pre\u2010clinically as part of a program to develop an alternative modality for treating prostate cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Spontaneous canine prostate cancer and normal canine prostate were used as the animal models. Interstitial PDT was performed by IV infusion of the photosensitizer and irradiating the prostates with a diode laser (763 nm). The prostates were harvested 1\u2010week post\u2010PDT and subjected to histopathologic examinations. The effects of the drug doses and light doses were studied for one\u2010 and two\u2010session PDT. Pharmacokinetics were studied using HPLC assay. The feasibility of using perfusing CT scans for assessing PDT lesions was also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tookad is a vascular\u2010acting drug and clears rapidly from the circulation. Tookad\u2010PDT\u2010induced lesions, in both normal and cancerous prostates, were characterized by marked hemorrhagic necrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tookad\u2010PDT is very effective in ablating prostatic tissue through its vascular effects. Lasers Surg. Med. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.20177","type":"journal-article","created":{"date-parts":[[2005,4,26]],"date-time":"2005-04-26T16:52:51Z","timestamp":1114534371000},"page":"390-397","source":"Crossref","is-referenced-by-count":71,"title":["Studies of a vascular\u2010acting photosensitizer, Pd\u2010bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate 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