{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:05:41Z","timestamp":1790885141485,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T00:00:00Z","timestamp":1129852800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Experimental assessment of anticancer effect, normal tissue damage, and toxicity of intrathoracic mTHPC\u2010mediated photodynamic therapy (PDT) combined to surgery in malignant pleural mesothelioma (MPM) bearing rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Six days after implantation of syngenic malignant mesothelioma cells in the left chest cavity of Fischer rats (n\u2009=\u200921) and 4 days after sensitization (0.1 mg\/kg mTHPC), a left\u2010sided pneumonectomy was performed, followed by intraoperative light delivery (652 nm, fluence 20 J\/cm<jats:sup>2<\/jats:sup>), either by spherical illumination of the chest cavity (fluence rate 15 mW\/cm<jats:sup>2<\/jats:sup>) or by focal illumination of a tumor area (fluence rate 150 mW\/cm<jats:sup>2<\/jats:sup>). Controls comprised tumor\u2010bearing untreated animals, tumor\u2010bearing animals undergoing pneumonectomy, and tumor\u2010bearing animals undergoing pneumonectomy and light delivery without sensitization or sensitization without light delivery. No thoracocentesis was performed during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An invasively growing sarcomatous type of mesothelioma was found in all animals at day 10, without tumor necrosis in control animals. PDT resulted in 0.5\u20131 mm deep inhomogeneous tumor necrosis after spherical, and in a 1\u20132 mm deep tumor necrosis after focal illumination. No injury to mediastinal organs was observed, neither after PDT with spherical nor with focal light delivery except focal interstitial lung fibrosis at the mediastinal area of the opposite lung. All animals with pneumonectomy followed by spherical PDT of the entire tumor\u2010bearing chest cavity died within 72 hours whereas all other animals survived. All animals that died presented massive pleural effusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PDT following pneumonectomy in mesothelioma bearing rats was technically feasible and allowed to study its effect on tumor and normal tissues. PDT\u2010related tumor necrosis was observed after spherical and focal light delivery, however, pneumonectomy followed by PDT with spherical light delivery to the tumor\u2010bearing chest cavity resulted in fatal complications. Lasers Surg. 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