{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T09:43:25Z","timestamp":1779097405537,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,8,15]],"date-time":"2006-08-15T00:00:00Z","timestamp":1155600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives:<\/jats:title><jats:p>Many treatment modalities exist for actinic keratoses (AK). Topical 5\u2010fluorouracil (5\u2010FU) has been one of the standard treatments. Laser resurfacing is a more recent treatment option. In the literature prospective randomized studies comparing these treatments are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Patients and Methods:<\/jats:title><jats:p>Prospective randomized study to compare topical 5\u2010FU with Er:YAG laser resurfacing. Fifty\u2010five patients with multiple AK on the scalp and or the face were included. Clinical and histopathological evaluation took place at 3, 6, and 12 months after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>At 3, 6, and 12 months after treatment, there were significantly less recurrences in the laser group compared to the group of patients treated with 5\u2010FU. Side effects did occur more frequently in the laser group, especially erythema and hypopigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Compared to treatment with topical 5\u2010FU, Er:YAG laser resurfacing is more effective regarding recurrence rates. Although significantly more side effects occur, laser resurfacing is a useful therapeutic option especially in patients with widespread AK. Lasers Surg. Med. 38:731\u2013739, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.20379","type":"journal-article","created":{"date-parts":[[2006,8,15]],"date-time":"2006-08-15T19:46:22Z","timestamp":1155671182000},"page":"731-739","source":"Crossref","is-referenced-by-count":43,"title":["A clinical comparison and long\u2010term follow\u2010up of topical 5\u2010fluorouracil versus laser resurfacing in the treatment of widespread actinic keratoses"],"prefix":"10.1002","volume":"38","author":[{"given":"Judith U.","family":"Ostertag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia J.F.","family":"Quaedvlieg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"van der 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