{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:48:42Z","timestamp":1791539322159,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,9,18]],"date-time":"2006-09-18T00:00:00Z","timestamp":1158537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Laser treatment using a 1,450 nm diode laser has been shown to improve acne and acne scarring. Its widespread adoption in younger populations has been significantly limited by discomfort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Six subjects with active papular acne were treated in a pilot study to determine parameters for a split\u2010face, double\u2010pass, low\u2010energy protocol of 1,450 nm laser treatment. Sides of the face were randomized to receive single\u2010pass, high\u2010energy treatment (13\u201314 J\/cm<jats:sup>2<\/jats:sup>), or double\u2010pass, low energy treatment (8\u201311 J\/cm<jats:sup>2<\/jats:sup>), for a total of four treatments delivered at monthly intervals. Acne counts and standardized, digital photograph were performed 2 months following the final treatment, and compared to pre\u2010treatment counts and photographs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Improvement was evaluated comparing pre\u2010 and post\u2010treatment photos and averaged 2.5 for the high\u2010energy, single\u2010pass side and 2.3 for the low\u2010energy, double\u2010pass side, using a 0 (worse) to 4 (max improvement) scale. Acne counts were reduced 78% on the high\u2010energy, single\u2010pass side and 67% on the low\u2010energy, double\u2010pass side. Pain ratings on a 1 (min) to 10 (max) scale averaged 5.6 (range 1\u20139) for the high\u2010energy, single\u2010pass side and 1.3 (range 1\u20132) for the low\u2010energy, double\u2010pass side.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low\u2010energy, double\u2010pass 1,450 nm laser treatment effectively reduces acne counts 2 months post\u2010treatment, and dramatically reduces the pain associated with treatment. The treatment parameters used in this study have eliminated the need for anesthetic cream in daily practice. Lasers Surg. Med. 39:193\u2013198, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.20401","type":"journal-article","created":{"date-parts":[[2006,9,18]],"date-time":"2006-09-18T21:54:58Z","timestamp":1158616498000},"page":"193-198","source":"Crossref","is-referenced-by-count":18,"title":["A pilot investigation comparing low\u2010energy, double pass 1,450 nm laser treatment of acne to conventional single\u2010pass, high\u2010energy treatment"],"prefix":"10.1002","volume":"39","author":[{"given":"Eric 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ultraviolet therapy of seborrhea and acne with the KUF\u20103 lamp","volume":"60","author":"Shteinberg MA","year":"1964","journal-title":"Voen Med Zh"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2003.tb00644.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/14764170310001276"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30053.x"},{"key":"e_1_2_1_15_2","first-page":"353","article-title":"Lasers, light, and acne","volume":"71","author":"Hirsch RJ","year":"2003","journal-title":"Cutis"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000246114"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03481.x"},{"key":"e_1_2_1_18_2","first-page":"393","article-title":"A single\u2010center study of aminolevulinic acid and 417 nm photodynamic therapy in the treatment of moderate to severs acne vulgaris","volume":"2","author":"Goldman 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