{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:53Z","timestamp":1786978313417,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:00:00Z","timestamp":1171929600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2007,2]]},"abstract":"Abstract<\/jats:title>\n \n Background and Objective<\/jats:title>\n Light\u2010emitting diode (LED) photomodulation increases dermal collagen and reduces inflammation. This study evaluated the use of LED photomodulation in the prevention of radiation\u2010induced dermatitis in breast cancer.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n Patients (\n n<\/jats:italic>\n \u2009=\u200919) were treated with LED photomodulation (Gentlewaves\u2122, Light BioScience, LLC, Virginia Beach, VA) after each of a series of intensity\u2010modulated radiation treatments (IMRT). Skin reactions were monitored weekly with National Cancer Institute (NCI) criteria. Age\u2010matched controls (\n n<\/jats:italic>\n \u2009=\u200928) received IMRT without LED photomodulation.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In LED\u2010treated patients, 18 (94.7%) had grade 0 or 1 reaction and 1 (5.3%) had grade 2 reaction. Among controls, 4 (14.3%) had a grade 1 reaction, 24 (85.7%) had a grade 2 or 3 reaction. One LED\u2010treated patient (5.3%) and 19 controls (67.9%) had to interrupt treatment.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n LED photomodulation treatments immediately after IMRT reduces the incidence of NCI grades 1, 2, and 3 skin reactions in patients with breast cancer treated by radiation therapy (RT) postlumpectomy. Lasers Surg. Med. 39:164\u2013168, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lsm.20455","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T13:26:32Z","timestamp":1171977992000},"page":"164-168","source":"Crossref","is-referenced-by-count":89,"title":["Treatment of radiation\u2010induced dermatitis with light\u2010emitting diode (LED) photomodulation"],"prefix":"10.1002","volume":"39","author":[{"given":"M. Maitland","family":"DeLand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"McDaniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy G.","family":"Geronemus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00782-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.054"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1188\/04.ONF.237-247"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00060-C"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/028418600750013159"},{"key":"e_1_2_1_7_2","first-page":"22","article-title":"Non\u2010ablative, LED photomodulation\u2014Light activated fibroblast stimulation clinical trial","volume":"25","author":"Geronemus R","year":"2003","journal-title":"Lasers Surg Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20107"},{"key":"e_1_2_1_9_2","first-page":"605","article-title":"A novel non\u2010thermal non\u2010ablative full panel LED photomodulation device for reversal of photoaging: Digital microscopic and clinical results in various skin types","volume":"3","author":"Weiss RA","year":"2004","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_1_10_2","first-page":"S25","article-title":"Light\u2010tissue interactions II: Photothermolysis versus photomodulation clinical applications","volume":"14","author":"McDaniel DH","year":"2002","journal-title":"Lasers Surg Med"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/104454701753342758"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/104454702320901107"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000140866.97278.87"},{"key":"e_1_2_1_14_2","first-page":"801","article-title":"Prevention and treatment of acute radiation dermatitis: A literature review","volume":"19","author":"Sitton E","year":"1992","journal-title":"Oncol Nurs Forum"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(01)00327-9"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.20455","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.20455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T02:24:16Z","timestamp":1694485456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.20455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1002\/lsm.20455"],"URL":"https:\/\/doi.org\/10.1002\/lsm.20455","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}