{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:42:58Z","timestamp":1787802178390,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,2,27]],"date-time":"2008-02-27T00:00:00Z","timestamp":1204070400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dyspigmentation is a common cosmetic concern among Asians. Many individuals exhibit mixed pigmentary entities including melasma, flat\/small seborrheic keratoses, ephelides, solar lentigines and acquired bilateral nevus\u2010of\u2010Ota\u2010like macules (ABNOM). We term this phenomenon complex dyspigmentation (CD) and suggest that a combination strategy may be more efficacious than any singular modality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effectiveness of combined intense\u2010pulsed light (IPL) for global photorejuvenation along with Q\u2010switched ruby laser (QSRL) for targeted pigment dissolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Twenty\u2010five Korean women with CD (defined as &gt;2 types of facial pigmentary disorders) were initially treated with IPL followed by repeat treatments every 3\u20134 weeks as needed. The QSRL treatments, set at low fluence, were added either during the same session or within 1 week of the IPL treatment. Improvement was assessed by the patient, the treating physician and a blinded evaluation of pre\u2010 and post\u2010treatment photographs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using a 4\u2010point scale (1\u2009=\u2009poor, 2\u2009=\u2009fair, 3\u2009=\u2009good, 4\u2009=\u2009excellent), 19\/25 patients (76%) reporting good\u2010to\u2010excellent response (score \u201c3\u201d or \u201c4\u201d). Two independent physician assessment revealed that 15\/25 patients (60%) showed 76\u2013100% improvement while 19\/25 patients (76%) showed at least 50% improvement. Side\u2010effects were minimal: 3 patients had transient post\u2010inflammatory hyperpigmentation (12%) and 1 patient (4%) had linear hypopigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combination treatment with IPL and QSRL is an effective and safe treatment for CD among Asian patients. Lesers Surg. 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