{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:16:03Z","timestamp":1792656963251,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,2,27]],"date-time":"2008-02-27T00:00:00Z","timestamp":1204070400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>As photoprotection with traditional sunscreen presents some limitations, the use of non\u2010traditional treatments to increase skin resistance to ultraviolet (UV) induced damage would prove particularly appealing. The purpose of this pilot study was to test the potential of non\u2010thermal pulsed light\u2010emitting diode (LED) treatments (660 nm) prior to UV exposure in the induction of a state of cellular resistance against UV\u2010induced erythema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design\/Materials and Methods<\/jats:title>\n                    <jats:p>Thirteen healthy subjects and two patients with polymorphous light eruption (PLE) were exposed to 5, 6, or 10 LED treatments (660 nm) on an EXPERIMENTAL anterior thigh region. Individual baseline minimal erythema doses (MED) were then determined. UV radiation was thereafter performed on the LED EXPERIMENTAL and CONTROL anterior thigh areas. Finally, 24 hours post\u2010UV irradiation, LED pre\u2010treated MED responses were compared to the non\u2010treated sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Reduction of erythema was considered significant when erythema was reduced by &gt;50% on the LED\u2010treated side as opposed to CONTROL side. A significant LED treatment reduction in UV\u2010B induced erythema reaction was observed in at least one occasion in 85% of subjects, including patients suffering from PLE. Moreover, there was evidence of a dose\u2010related pattern in results. Finally, a sun protection factor SPF\u201015\u2010like effect and a reduction in post\u2010inflammatory hyperpigmentation were observed on the LED pre\u2010treated side.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Results suggest that LED based therapy prior to UV exposure provided significant protection against UV\u2010B induced erythema. The induction of cellular resistance to UV insults may possibly be explained by the induction of a state a natural resistance to the skin via specific cell signaling pathways and without the drawbacks and limitations of traditional sunscreens. These results represent an encouraging step towards expanding the potential applications of LED therapy and could be useful in the treatment of patients with anomalous reactions to sunlight. Lesers Surg. Med. 40:106\u2013112, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.20615","type":"journal-article","created":{"date-parts":[[2008,2,27]],"date-time":"2008-02-27T11:17:39Z","timestamp":1204111059000},"page":"106-112","source":"Crossref","is-referenced-by-count":40,"title":["LED photoprevention: Reduced MED response following multiple LED 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