{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:45Z","timestamp":1786978185834,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T00:00:00Z","timestamp":1208217600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Rosacea results from sun\u2010induced hyper\u2010vascularity of exposed facial skin, often accompanied by acneiform papules and pustules. The pulsed\u2010dye laser has an unparalleled safety record and emits an ideal wavelength for treating the abnormal vessels that occur in rosacea patients. In this study we investigate the ability of the long pulse\u2010duration pulsed\u2010dye laser to improve rosacea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design\/Materials and Methods<\/jats:title>\n                    <jats:p>Twenty subjects with rosacea were treated with the high\u2010energy, long pulse\u2010duration pulsed\u2010dye laser. An elliptical spot and long pulse\u2010duration was used to spot\u2010treat linear telangiectasias, while a circular spot and short pulse\u2010duration was used to treat the entire face. Improvement was determined by blinded evaluation of photographs and by the treating physician's subjective evaluation, before and 8 weeks following the final treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The average rosacea score as estimated by the treating physician decreased from 2.7\u00b11.1 to 1.4+ 0.7 (mean+SD) on a 0\u20136 scale with 0 representing no rosacea and 6 representing the most severe rosacea (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001 level). The average rosacea score as rated by blinded physician observers scoring digital photos was 2.3\u00b11.3 before treatment and 1.4\u00b10.9 8 weeks following treatment, using a 0 (mild) to 6 (severe) scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The high\u2010energy, long pulse\u2010duration pulsed\u2010dye laser improves rosacea with a very favorable safety profile, and less purpura than resulted from earlier generation pulsed\u2010dye lasers. Lesers Surg. Med. 40:233\u2013239, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.20621","type":"journal-article","created":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T18:08:49Z","timestamp":1208282929000},"page":"233-239","source":"Crossref","is-referenced-by-count":73,"title":["Rosacea treatment using the new\u2010generation, high\u2010energy, 595 nm, long pulse\u2010duration pulsed\u2010dye laser"],"prefix":"10.1002","volume":"40","author":[{"given":"Eric F.","family":"Bernstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Kligman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1997)20:1<1::AID-LSM1>3.0.CO;2-U"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.08253.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1998.tb04140.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2003.29383.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.11.1444"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20463"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20413"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1988.01670060035012"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902163200702"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199405000-00007"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992289002900902"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2001.00192.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2004.02.011"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.04.010"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30001.x"},{"key":"e_1_2_1_17_2","first-page":"522","article-title":"Flash lamp pumped dye laser for rosacea\u2010associated telangiectasia and erythema","volume":"17","author":"Lowe NJ","year":"1991","journal-title":"J Dermatol Surg Oncol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-198910000-00007"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.11.1345"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20373"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042728-200501000-00001"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30301.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20001"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2003.29386.x"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29290.x"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.20621","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.20621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T05:23:40Z","timestamp":1699939420000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.20621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1002\/lsm.20621"],"URL":"https:\/\/doi.org\/10.1002\/lsm.20621","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}