{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:57:39Z","timestamp":1782824259508,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,8,25]],"date-time":"2008-08-25T00:00:00Z","timestamp":1219622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>In the classic model of pleurisy there is little evidence about the anti\u2010inflammatory effects of low\u2010level laser therapy (LLLT) as well the dosage characteristics, such as wavelength, total energy, number and pattern of treatment. In this study we investigated the potential effects of LLLT on modulating the pro\u2010inflammatory and anti\u2010inflammatory mediators of acute inflammation in a rat pleurisy model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>A sample of 48 female Wistar rats were divided into control and experiential groups. An inflammation was induced by carrageenan (0.2 ml) injected into the pleural cavity. At 1, 2, and 3 hours after induction a continuous wave (20 mW) diode laser of the InGaAlP (660 nm) type was used in the four laser groups with different doses and treatment patterns. One group received a single dose of 2.1 J and the other three groups received a total energy of 0.9, 2.1, and 4.2 J. Four hours later the exudate volume, total and differential leukocytes, protein concentration, NO, IL\u20106, IL\u201010, TNF\u2010\u03b1, and MCP\u20101 were measured from the aspirated liquid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All the treatment patterns and quantity of energy studied show significant reduction of the exudate volume (<jats:italic>P<\/jats:italic>&lt;0.05). Using energy of 0.9 J only NO, IL\u20106, MCP\u20101 and IL\u201010 are significantly reduced (<jats:italic>P<\/jats:italic>&lt;0.05). On the other hand, higher energies (2.1 and 4.2 J) significantly reduce all variables independently of the treatment pattern. The neutrophil migration has a straight correlation with the TNF\u2010\u03b1 (<jats:italic>r<\/jats:italic>\u2009=\u20090.551) and NO (<jats:italic>r<\/jats:italic>\u2009=\u20090.549) concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LLLT\u2014660 nm induced an anti\u2010inflammatory effect characterized by inhibition of either total or differential leukocyte influx, exudation, total protein, NO, IL\u20106, MCP\u20101, IL\u201010, and TNF\u2010\u03b1, in a dose\u2010dependent manner. Under these conditions, laser treatment with 2.1 J was more effective than 0.9 and 4.2 J. Lesers Surg. Med. 40:500\u2013508, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.20658","type":"journal-article","created":{"date-parts":[[2008,8,25]],"date-time":"2008-08-25T15:28:40Z","timestamp":1219678120000},"page":"500-508","source":"Crossref","is-referenced-by-count":123,"title":["Anti\u2010Inflammatory effects of low\u2010level laser therapy (660 nm) in the early phase in carrageenan\u2010induced pleurisy in rat"],"prefix":"10.1002","volume":"40","author":[{"given":"Emerson S.","family":"Boschi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasyl 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