{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T12:57:28Z","timestamp":1774184248317,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,18]],"date-time":"2009-02-18T00:00:00Z","timestamp":1234915200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Pulsed carbon dioxide (CO<jats:sub>2<\/jats:sub>) laser devices are considered highly effective treatment options for skin resurfacing. However, the high risk for significant treatment complications following CO<jats:sub>2<\/jats:sub> resurfacing has warranted the development of new treatment modalities. The concept of fractional photothermolysis was developed to address the shortcomings of ablative and non\u2010ablative device modalities. This report evaluates a fractional approach to CO<jats:sub>2<\/jats:sub> laser resurfacing for the treatment of moderate to severe acne scarring. The primary endpoint of the study was the overall improvement in the appearance of acne scarring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Thirty subjects, with moderate to severe acne scarring, underwent up to three treatments with an FDA IDE and IRB approved 10,600 nm fractional CO<jats:sub>2<\/jats:sub> laser system. All subjects were Fitzpatrick skin types I\u2013V and 18\u201375 years of age. Treatment parameters ranged from 20 to 100 mJ with total densities of 600\u20131,600 MTZ\/cm<jats:sup>2<\/jats:sup>. Improvement of acne scarring was evaluated at 1 and 3 months post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three out of 25 subjects sustained clinical improvement in the appearance of acne scarring at the 3\u2010month follow\u2010up visits according to study investigator quartile improvement scoring. Subjects also had improvement in their overall appearance, including pigmentation and rhytides. Serosanguinous oozing resolved within 24\u201348 hours following treatment. All subjects had transient erythema, which resolved in the majority of subjects within 1\u20133 months. Post\u2010operative downtime was significantly decreased compared to traditional ablative resurfacing. No serious complications were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fractional deep dermal ablation improves moderate to severe acne scarring. The added benefit is a considerable reduction both in downtime and risk of complications when compared to traditional CO<jats:sub>2<\/jats:sub> ablative resurfacing techniques. Lasers Surg. Med. 41:122\u2013127, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.20725","type":"journal-article","created":{"date-parts":[[2009,2,18]],"date-time":"2009-02-18T21:36:19Z","timestamp":1234992979000},"page":"122-127","source":"Crossref","is-referenced-by-count":93,"title":["Evaluation of a novel fractional resurfacing device for treatment of acne scarring"],"prefix":"10.1002","volume":"41","author":[{"given":"Susan E.","family":"Walgrave","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arisa E.","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather T.","family":"MacFalls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Elkeeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne K.","family":"Truitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua A.","family":"Tournas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian D.","family":"Zelickson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher B.","family":"Zachary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.99232.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20617"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.99115.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1998.tb04161.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33003.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/14764170600607251"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33059.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20405"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20468"},{"key":"e_1_2_1_11_2","article-title":"Fractional deep dermal ablation induces tissue tightening","author":"Rahman Z","journal-title":"Lasers Surg Med"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29012.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20659"},{"issue":"9","key":"e_1_2_1_14_2","first-page":"7","article-title":"Fractional laser treatment for pigmentation and texture improvement","volume":"11","author":"Rahman Z","year":"2006","journal-title":"Skin Therapy Lett"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20484"},{"key":"e_1_2_1_16_2","volume-title":"Fractional resurfacing in plastic surgery","author":"Burns AJ","year":"2005"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2002.02832.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.11.1337"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.20725","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.20725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T15:55:26Z","timestamp":1694534126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.20725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1002\/lsm.20725"],"URL":"https:\/\/doi.org\/10.1002\/lsm.20725","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}