{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T19:31:07Z","timestamp":1778787067769,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T00:00:00Z","timestamp":1231804800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>This preliminary report describes a new laser\u2010assisted treatment option for the emerging complication of bisphosphonate related osteonecrosis (BON) of the jaw.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In eight tumour patients (three women, five men) ten bony lesions in the maxilla and mandible in the course of intravenous bisphosphonate therapy were treated with a variable square pulsed (VSP) Er:YAG laser. For the treatment, the Er:YAG laser was applied with a pulse energy of 1,000 mJ, a pulse duration of 300 microseconds, and a frequency of 12 Hz (energy density 157 J\/cm<jats:sup>2<\/jats:sup>). The spot size was 0.9 mm and the handpiece was kept at a distance of about 10 mm from the bone surface. The diseased bone was ablated exclusively with the Er:YAG laser by subsequently sweeping the bone surface in a well directed scanning mode.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The surgical procedure and postoperative wound healing were without any complications and a complete soft tissue recovering was achieved within 4 weeks. During follow\u2010up examinations over 12 months soft tissue conditions were stable. The pulsed laser ablation caused a characteristic microstructured and craggy bone surface without a condensation or a smear layer on the laser rims.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The bone ablation technique using a VSP Er:YAG laser yielded promising clinical results without impairment of wound healing. A further analyse of the chemical, physical and pharmacological aspects of laser assisted treatment of BON lesions is necessary to get a safe and reliable treatment protocol for bisphosphonate\u2010related osteonecrosis of the jaw. Lasers Surg. Med. 41:26\u201330, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.20730","type":"journal-article","created":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T19:54:27Z","timestamp":1231876467000},"page":"26-30","source":"Crossref","is-referenced-by-count":36,"title":["A preliminary report about treatment of bisphosphonate related osteonecrosis of the jaw with Er:YAG laser ablation"],"prefix":"10.1002","volume":"41","author":[{"given":"Stefan","family":"St\u00fcbinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2010Philipp","family":"Dissmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole Chambron","family":"Pinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belma","family":"Saldamli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Sader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.8670"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000187398.51857.3c"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2007.06.008"},{"key":"e_1_2_1_5_2","first-page":"265","article-title":"Uptake by bone of pyrophosphate, diphosphonates and their technetium derivatives","volume":"54","author":"Bisaz S","year":"1978","journal-title":"Clin Sci Mol Med"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650070507"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-003-0008-5"},{"key":"e_1_2_1_8_2","first-page":"6538","article-title":"Bisphosphonates inhibit angiogenesis in vitro and testosterone\u2010stimulated vascular regrowth in the ventral prostate in castrated rats","volume":"62","author":"Fournier P","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200422087"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650020209"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.11.003"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2007.2181"},{"key":"e_1_2_1_14_2","first-page":"22","article-title":"Clinical application of erbium:YAG laser in periodontology","volume":"10","author":"Ishikawa I","year":"2008","journal-title":"J Int Acad Periodontol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900120203"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20528"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000258559.07435.b3"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.20730","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.20730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T23:48:27Z","timestamp":1700005707000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.20730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1002\/lsm.20730"],"URL":"https:\/\/doi.org\/10.1002\/lsm.20730","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}