{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T19:02:27Z","timestamp":1778353347060,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,3,16]],"date-time":"2009-03-16T00:00:00Z","timestamp":1237161600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH\/NIDR","award":["R01-DE14698"],"award-info":[{"award-number":["R01-DE14698"]}]},{"name":"NIH\/NIDR","award":["R01-DE17869"],"award-info":[{"award-number":["R01-DE17869"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Sound enamel manifests peak transparency in the near\u2010IR (NIR) at 1310\u2010nm, therefore the near\u2010IR is ideally suited for high contrast imaging of dental caries. The purpose of this study was to acquire images of early demineralized enamel on the buccal and occlusal surfaces of extracted human teeth using NIR reflectance imaging and compare the contrast of those images with the contrast of images taken using other methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Fifteen human molars were used in this in vitro study. Teeth were painted with a clear acid\u2010resistant varnish, leaving two 2 mm\u2009\u00d7\u20092 mm windows on the buccal and occlusal surfaces of each tooth for demineralization. Artificial lesions were produced in the exposed windows after a 2\u2010day exposure to a demineralizing solution at pH 4.5. Lesions were imaged using NIR transillumination, NIR and visible light reflectance, and fluorescence imaging methods. Crossed polarizers were used where appropriate to improve contrast. Polarization sensitive optical coherence tomography (PS\u2010OCT) was also used to non\u2010destructively assess the depth and severity of demineralization in each sample window.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NIR reflectance imaging had the highest image contrast for both the buccal and occlusal groups and it was significantly higher contrast than visible light reflectance (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of the study suggest that NIR reflectance imaging is a promising new method for acquiring high contrast images of early demineralization on tooth surfaces. Lasers Surg. Med. 41:208\u2013213, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.20746","type":"journal-article","created":{"date-parts":[[2009,4,3]],"date-time":"2009-04-03T15:19:06Z","timestamp":1238771946000},"page":"208-213","source":"Crossref","is-referenced-by-count":49,"title":["High contrast near\u2010infrared polarized reflectance images of demineralization on tooth buccal and occlusal surfaces at <i>\u03bb<\/i>\u2009=\u20091310\u2010nm"],"prefix":"10.1002","volume":"41","author":[{"given":"J.","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Fried","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","unstructured":"NIH: Diagnosis and Management of Dental Caries throughout Life 1\u201024 (NIH Consensus Statement 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