{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:49:02Z","timestamp":1761630542664},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T00:00:00Z","timestamp":1266364800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Treatment of recalcitrant viral warts remains a therapeutic challenge. Intense pulsed light (IPL) has been suggested effective to clear wart tissue. The objective was in a randomized controlled trial to assess the efficacy of paring followed by IPL versus paring alone for recalcitrant hand and foot warts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Eighty\u2010nine patients with recalcitrant hand and foot warts were included and randomized (1:1) to three treatments at 3\u2010week intervals with either paring of warts followed by IPL or paring of warts alone. IPL was given with the Ellipse Flex IPL system (Danish Dermatologic Development A\/S, H\u00f8rsholm, Denmark, 400\u2013950\u2009nm, 5.5\u2009millisecond pulse duration in double pulses with a 2\u2009millisecond interval, 26.0\u201332.5\u2009J\/cm<jats:sup>2<\/jats:sup> repetitive passes). The primary outcome was complete and partial clearance of warts evaluated by blinded photo assessment at 6 weeks after final treatment. Secondary outcomes were treatment related pain and adverse reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found no significant difference in clearance of warts between the two intervention groups (OR 1.64, 95% confidence interval 0.62\u20134.38). Paring followed by IPL resulted in complete or partial clearance of wart tissue in nine (22%) and five patients (12.2%) versus five (13.5%) and four patients (10.8%) from paring alone. Mostly plantar warts were treated (92.1%). The pain intensity after paring and IPL was moderate and significantly higher than the pain intensity after paring alone (<jats:italic>P<\/jats:italic>&lt;0.0005). No adverse reactions were observed from the two interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Paring followed by IPL did not differ significantly from paring alone in clearance of recalcitrant hand and foot warts but caused significantly more pain. Lasers Surg. Med. 42:179\u2013184, 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.20852","type":"journal-article","created":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T20:08:15Z","timestamp":1266437295000},"page":"179-184","source":"Crossref","is-referenced-by-count":13,"title":["Paring and intense pulsed light versus paring alone for recalcitrant hand and foot warts: A randomized clinical trial with blinded outcome evaluation"],"prefix":"10.1002","volume":"42","author":[{"given":"Katrine","family":"Togsverd\u2010Bo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Gluud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Winkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helle K.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans B.","family":"Lomholt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Cramers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bjerring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merete","family":"H\u00e6dersdal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,2,17]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"107","article-title":"Skin disease in Lambeth: A community study of prevalence and use of medical care","volume":"30","author":"Rea JN","year":"1976","journal-title":"Br J Prev Soc Med"},{"key":"e_1_2_1_3_2","first-page":"69","article-title":"Warts on the hands. A statistical survey","volume":"55","author":"Barr A","year":"1969","journal-title":"Trans St John's Hosp Derm Soc"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590150022004"},{"issue":"3","key":"e_1_2_1_5_2","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001781.pub2","article-title":"Topical treatments for cutaneous warts","author":"Gibbs S","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900130120"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.4.12.1035"},{"key":"e_1_2_1_8_2","first-page":"230","article-title":"Treatment of recalcitrant warts using pulsed dye laser","volume":"56","author":"Webster GF","year":"1995","journal-title":"Cutis"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.07165.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1997)21:5<500::AID-LSM13>3.0.CO;2-C"},{"key":"e_1_2_1_11_2","first-page":"206","article-title":"Pulsed dye laser efficacy as initial therapy for warts and against recalcitrant verrucae","volume":"59","author":"Jacobsen E","year":"1997","journal-title":"Cutis"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjps.1999.3121"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01994.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.34010.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01679.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2008.00509.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.106365"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1996.tb00027.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050170084"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.12.006"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj069"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39465.451748.AD"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20326"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20634"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2002.02117.x"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.10036"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.20852","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.20852","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.20852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T11:53:51Z","timestamp":1700654031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.20852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1002\/lsm.20852"],"URL":"https:\/\/doi.org\/10.1002\/lsm.20852","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}