{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:00:29Z","timestamp":1773086429255,"version":"3.50.1"},"reference-count":3,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T00:00:00Z","timestamp":1266364800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Reliant Technologies"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Recently, there has been much debate regarding the long\u2010term efficacy of fractional resurfacing devices. While pulsed CO<jats:sub>2<\/jats:sub> laser resurfacing is considered a highly effective treatment, fractionated resurfacing is a newer modality and its long\u2010term efficacy has yet to be assessed. We report the long\u2010term outcomes of subjects previously treated with fractional CO<jats:sub>2<\/jats:sub> resurfacing for photodamaged skin and acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Ten subjects from our previous studies who received fractional resurfacing for the treatment of acne scarring and photodamage returned for long\u2010term follow\u2010up visits at 1 and 2 years, respectively. Investigators graded maintenance of improvement on a quartile scale based on clinical photography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subjects maintained 74% of their overall improvement at their long\u2010term visits compared to 3\u2010month follow\u2010up visits. While clinical improvement was maintained long\u2010term, the results were not as remarkable as those seen at 3\u2010month visits. The authors speculate that results seen at 3 months may be enhanced by persistent inflammatory changes, as evidenced by heat shock protein 47 activity and ongoing collagen remodeling seen in previous histologic studies. Relaxation of tightening is to be expected with any procedure along with the natural progression of aging. However, patient satisfaction was upheld long\u2010term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fractional CO<jats:sub>2<\/jats:sub> laser resurfacing does have long\u2010term efficacy and persistence of improvement of acne scarring and photodamage compared to baseline. However, additional treatments may be necessary to enhance long\u2010term results. Lasers Surg. Med. 42:168\u2013170, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.20885","type":"journal-article","created":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T20:07:50Z","timestamp":1266437270000},"page":"168-170","source":"Crossref","is-referenced-by-count":62,"title":["Long\u2010term efficacy of a fractional resurfacing device"],"prefix":"10.1002","volume":"42","author":[{"given":"Arisa E.","family":"Ortiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Marie","family":"Tremaine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher B.","family":"Zachary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,2,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20725"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20715"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20468"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.20885","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.20885","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.20885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T11:53:10Z","timestamp":1700653990000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.20885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":3,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1002\/lsm.20885"],"URL":"https:\/\/doi.org\/10.1002\/lsm.20885","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}