{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T02:14:51Z","timestamp":1768616091945,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T00:00:00Z","timestamp":1269302400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The possible interference of combined laser hair removal and Botulinum toxin A (BoNT\/A) injections in the treatment of axillary hyperhidrosis has not previously been explored. In order to examine this potential interference, we assessed the effect of BoNT\/A on axillary hyperhidrosis with and without concomitant diode laser axillary hair removal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>In a prospective, double blind, randomized cross over trial, nine patients suffering from primary axillary hyperhidrosis were laser\u2010treated on one randomly assigned axilla. One week later, both axillas were injected intradermally with BoNT\/A (100\u2009MU per axilla). During the same session, the previously untreated axilla was lasered. Axillary sweat rates (in g\/5\u2009minutes.) were determined by gravimetry and compared at rest, during mental exercise, and during physical exercise. Additionally, subjective outcome measures were assessed by a visual analogue scale, Dermatology Life Quality Index, and Global Clinical Impression score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No differences were found regarding the effect of BoNT\/A on previously laser\u2010treated and laser co\u2010treated sides over time course for any of the outcome parameters. Sweat production was reduced 3 weeks after BoNT\/A treatment by 93.5% at rest, 96.5% during mental exercise, and 67% during physical exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Concomitant laser hair removal does not interfere with BoNT\/A treatment on axillary hyperhidrosis. Lasers Surg. Med. 42:211\u2013214, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.20891","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T16:27:33Z","timestamp":1269361653000},"page":"211-214","source":"Crossref","is-referenced-by-count":12,"title":["Diode laser hair removal does not interfere with botulinum toxin A treatment against axillary hyperhidrosis"],"prefix":"10.1002","volume":"42","author":[{"given":"Anna","family":"Paul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gottfried","family":"Kranz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schindl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg S.","family":"Kranz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Auff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Sycha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1998.tb04104.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836297"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.5978\/islsm.8.233"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(2000)26:2<108::AID-LSM2>3.0.CO;2-4"},{"issue":"10","key":"e_1_2_1_6_2","first-page":"42","article-title":"Hair removal by a pulsed, infrared laser system","volume":"22","author":"Dierickx CC","year":"1998","journal-title":"Laser Surg Med"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31105"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1136"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1139\/m72-016"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32338.x"},{"key":"e_1_2_1_11_2","first-page":"2120","article-title":"Dermatology life quality index (DLQI): A simple practical measure for routine clinical use","volume":"19","author":"Filay AY","year":"1994","journal-title":"Clin Exp Dermatol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.08244.x"},{"key":"e_1_2_1_13_2","first-page":"695","article-title":"Studies on thermal injury I. The relative importance importance of time and surface temperature in the causation of cutaneous burns","volume":"23","author":"Henriques FC","year":"1947","journal-title":"Am J Pathol"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.20891","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.20891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T11:29:13Z","timestamp":1700652553000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.20891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1002\/lsm.20891"],"URL":"https:\/\/doi.org\/10.1002\/lsm.20891","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}