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The LED parameters was 22\u2009mW CW of optical output power, distributed in an irradiation area of 0.5\u2009cm<jats:sup>2<\/jats:sup>, with an irradiation time of 170\u2009seconds, the applied energy density was 7.5\u2009J\/cm<jats:sup>2<\/jats:sup> in contact. The therapy was initiated 12\u2009hours after the tendinitis induction, with a 48\u2010hour interval between the irradiations. The histological analysis and inflammatory mediators were quantified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed that LED decreases the inflammatory cells influx and mRNA expression to IL\u20101\u03b2, IL\u20106, tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) in both phase, and cyclooxygenase\u20102 (COX\u20102) just in initial phase (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that the anti\u2010inflammatory therapy with low\u2010power LED (880\u2009nm) enhanced the tissue response in all groups. We can conclude that the LED was able to reduce signs of inflammation in collagenase\u2010induced tendinitis in rats by reducing the number of inflammatory cells and decrease mRNA expression of cytokines. Lasers Surg. Med. 42:553\u2013558, 2010. \u00a9 2010 Wiley\u2013Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.20896","type":"journal-article","created":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T18:28:55Z","timestamp":1279650535000},"page":"553-558","source":"Crossref","is-referenced-by-count":87,"title":["Anti\u2010inflammatory effects of low\u2010level light emitting diode therapy on achilles tendinitis in rats"],"prefix":"10.1002","volume":"42","author":[{"given":"Murilo","family":"Xavier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Rodrigues","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Aparecido","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur 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