{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:35:25Z","timestamp":1789590925968,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,3,15]],"date-time":"2011-03-15T00:00:00Z","timestamp":1300147200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Photodynamic therapy (PDT) is a minimally invasive surgical intervention used in the management of tissue disorders. It can be applied before, or after, any of the conventional modalities, without compromising these treatments or being compromised itself.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this prospective study, a total of 147 consecutive patients with oral potentially malignant disorders were treated with surface illumination PDT, using 5\u2010ALA or mTHPC as the photosensitizer. The average age was 53\u2009\u00b1\u20098.9 years. The patients' recovery was uneventful and no complications reported. Comparisons with the clinical and histopathological features and rate of recurrence as well as malignant transformation were made. The patients were followed\u2010up for a mean of 7.3 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Analysis and Results<\/jats:title><jats:p>Homogenous leukoplakias were identified in 55 patients, non\u2010homogenous leukoplakias in 73 patients, whereas 19 patients had erythroplakias. Ex\u2010 and current lifelong smokers formed 84.4% of the recruited patients. While people who currently smoke and drink formed 38.1% (56 patients) of the cohort. Erythroplakias were mainly identified in heavy lifelong smokers. The most common identified primary anatomical locations were the lateral border of tongue, floor of mouth and retromolar area. Moderate dysplasia was identified in 33 patients while 63 patients had severe dysplasias; and 32 patients had a histopathological diagnosis of carcinoma in situ.<\/jats:p><jats:p>The rate of recurrence in laser surgery was approximately 11.6%. Malignant transformation was observed in 11 patients (7.5%), in the tongue, floor of mouth and retromolar area. Recurrence and malignant transformation was mainly identified in erythroplakias and non\u2010homogenous leukoplakias. The final outcome of the cohort showed that 11 (7.5%) suffered from progressive disease, 5 (3.4%) had stable disease, 12 (8.2%) were considered partially responsive to the therapy. Complete response was identified in 119\/147 patients (81%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>5\u2010ALA\u2010PDT and\/or mTHPC\u2010PDT offer an effective alternative treatment for oral potentially malignant disorders. Lasers Surg. Med. 43:192\u2013199, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.21036","type":"journal-article","created":{"date-parts":[[2011,3,15]],"date-time":"2011-03-15T15:21:10Z","timestamp":1300202470000},"page":"192-199","source":"Crossref","is-referenced-by-count":76,"title":["Photodynamic therapy outcome for oral dysplasia"],"prefix":"10.1002","volume":"43","author":[{"given":"Waseem","family":"Jerjes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahwinder","family":"Upile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid","family":"Hamdoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Alexander","family":"Mosse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Akram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Hopper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,15]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.016"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.02.016"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21131"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(00)00166-2"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2007.34.8.478"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20853"},{"key":"e_1_2_5_8_2","volume-title":"World Health Organization classification of tumours. 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