{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T02:35:31Z","timestamp":1787538931990,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T00:00:00Z","timestamp":1308009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>It is unknown if pro\u2010 and anti\u2010inflammatory mediators in acute lung inflammation induced by intestinal ischemia and reperfusion (i\u2010I\/R) can be modulated by low\u2010level laser therapy (LLLT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Material and Methods<\/jats:title><jats:p>A controlled ex vivo study was developed in which rats were irradiated (660\u2009nm, 30\u2009mW, 0.08\u2009cm<jats:sup>2<\/jats:sup> of spot size) on the skin over the right upper bronchus 1\u2009hour post\u2010mesenteric artery occlusion and euthanized 4\u2009hours later. For pretreatment with anti\u2010tumor necrosis factor (TNF) or IL\u201010 antibodies, the rats received either one of the agents 15\u2009minutes before the beginning of reperfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lung edema was measured by the Evans blue extravasation and pulmonary neutrophils influx was determined by myeloperoxidase (MPO) activity. Both TNF and IL\u201010 expression and protein in lung were evaluated by RT\u2010PCR and ELISA, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LLLT reduced the edema (80.1\u2009\u00b1\u200941.8\u2009\u00b5g\u2009g<jats:sup>\u22121<\/jats:sup>\u2009dry weight), neutrophils influx (0.83\u2009\u00b1\u20090.02\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>\u2009cells\u2009ml<jats:sup>\u22121<\/jats:sup>), MPO activity (2.91\u2009\u00b1\u20090.60), and TNF (153.0\u2009\u00b1\u200921.0\u2009pg\u2009mg<jats:sup>\u22121<\/jats:sup>\u2009tissue) in lung when compared with respective control groups. Surprisingly, the LLLT increased the IL\u201010 (0.65\u2009\u00b1\u20090.13) in lung from animals subjected to i\u2010I\/R. Moreover, LLLT (0.32\u2009\u00b1\u20090.07\u2009pg\u2009ml<jats:sup>\u22121<\/jats:sup>) reduced the TNF\u2010\u03b1 level in RPAECs when compared with i\u2010I\/R group. The presence of anti\u2010TNF or IL\u201010 antibodies did not alter the LLLT effect on IL\u201010 (465.1\u2009\u00b1\u200921.0\u2009pg\u2009mg<jats:sup>\u22121<\/jats:sup>\u2009tissue) or TNF (223.5\u2009\u00b1\u200921.0\u2009pg\u2009mg<jats:sup>\u22121<\/jats:sup>\u2009tissue) in lung from animals submitted to i\u2010I\/R.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results indicate that the LLLT attenuates the i\u2010I\/R\u2010induced acute lung inflammation which favor the IL\u201010 production and reduce TNF generation. Lasers Surg. Med. 43:410\u2013420, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.21053","type":"journal-article","created":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T09:20:25Z","timestamp":1308129625000},"page":"410-420","source":"Crossref","is-referenced-by-count":98,"title":["Dual Effect of low\u2010level laser therapy (LLLT) on the acute lung inflammation induced by intestinal ischemia and reperfusion: Action on anti\u2010 and pro\u2010inflammatory cytokines"],"prefix":"10.1002","volume":"43","author":[{"given":"F. 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