{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:28:52Z","timestamp":1791206932194,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1470,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"crossref","award":["R21-DE0-18782"],"award-info":[{"award-number":["R21-DE0-18782"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg. Med."],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1002\/lsm.21069","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T19:48:48Z","timestamp":1444765728000},"page":"600-606","source":"Crossref","is-referenced-by-count":102,"title":["Photodynamic effects of methylene blue-loaded polymeric nanoparticles on dental plaque bacteria"],"prefix":"10.1002","volume":"43","author":[{"given":"Vanja","family":"Klepac-Ceraj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niraj","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Holewa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitrang","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Kent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoor M.","family":"Amiji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos S.","family":"Soukos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,23]]},"reference":[{"issue":"1","key":"10.1002\/lsm.21069-BIB1|cit1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1600-0757.2009.00339.x","article-title":"Dental plaque biofilms: Communities, conflict and control","volume":"55","author":"Marsh","year":"2011","journal-title":"Periodontology 2000"},{"key":"10.1002\/lsm.21069-BIB2|cit2","first-page":"85","article-title":"Innate and induced resistance mechanisms of bacterial biofilms","volume":"322","author":"Anderson","year":"2008","journal-title":"Curr Top Microbiol Immunol"},{"issue":"4","key":"10.1002\/lsm.21069-BIB3|cit3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2672.1993.tb02780.x","article-title":"Photolysis of oral bacteria and its potential use in the treatment of caries and periodontal disease","volume":"75","author":"Wilson","year":"1993","journal-title":"J Appl Bacteriol"},{"issue":"12","key":"10.1002\/lsm.21069-BIB4|cit4","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/jnci\/90.12.889","article-title":"Photodynamic therapy","volume":"90","author":"Dougherty","year":"1998","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"10.1002\/lsm.21069-BIB5|cit5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1600-0757.2010.00346.x","article-title":"Photodynamic therapy in the control of oral biofilms","volume":"55","author":"Soukos","year":"2011","journal-title":"Periodontology 2000"},{"issue":"7","key":"10.1002\/lsm.21069-BIB6|cit6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1600-051X.2009.01412.x","article-title":"Clinical effectiveness of photodynamic therapy in the treatment of periodontitis","volume":"36","author":"Polansky","year":"2009","journal-title":"J Clin Periodontol"},{"issue":"10","key":"10.1002\/lsm.21069-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1902\/jop.2009.090206","article-title":"Short-term effects of photodynamic therapy on periodontal status and glycemic control of patients with diabetes","volume":"80","author":"Al-Zahrani","year":"2009","journal-title":"J Periodontol"},{"issue":"6","key":"10.1002\/lsm.21069-BIB8|cit8","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00784-009-0347-4","article-title":"Photodynamic therapy of persistent pockets in maintenance patients-A clinical study","volume":"14","author":"Ruhling","year":"2010","journal-title":"Clin Oral Investig"},{"issue":"1","key":"10.1002\/lsm.21069-BIB9|cit9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1902\/jop.2009.090285","article-title":"The effect of photodynamic therapy for periodontitis: A systematic review and meta-analysis","volume":"81","author":"Azarpazhooh","year":"2010","journal-title":"J Periodontol"},{"issue":"2","key":"10.1002\/lsm.21069-BIB10|cit10","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/sj.clpt.6100247","article-title":"The challenge of treating biofilm-associated bacterial infections","volume":"82","author":"del Pozo","year":"2007","journal-title":"Clin Pharmacol Ther"},{"issue":"6","key":"10.1002\/lsm.21069-BIB11|cit11","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.1600-0765.2008.01187.x","article-title":"The antibacterial effect of photodynamic therapy in dental plaque-derived biofilms","volume":"44","author":"Fontana","year":"2009","journal-title":"J Periodontal Res"},{"issue":"1","key":"10.1002\/lsm.21069-BIB12|cit12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/08959374970110010701","article-title":"Biofilm susceptibility to antimicrobials","volume":"11","author":"Gilbert","year":"1997","journal-title":"Adv Dent Res"},{"issue":"6","key":"10.1002\/lsm.21069-BIB13|cit13","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/jac\/22.6.777","article-title":"Resistance of bacterial biofilms to antibiotics: A growth-rate related effect?","volume":"22","author":"Brown","year":"1988","journal-title":"J Antimicrob Chemother"},{"issue":"6858","key":"10.1002\/lsm.21069-BIB14|cit14","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35101627","article-title":"Gene expression in Pseudomonas aeruginosa biofilms","volume":"413","author":"Whiteley","year":"2001","journal-title":"Nature"},{"issue":"7","key":"10.1002\/lsm.21069-BIB15|cit15","doi-asserted-by":"crossref","first-page":"R138","DOI":"10.1186\/gb-2007-8-7-r138","article-title":"Extensive genomic diversity and selective conservation of virulence-determinants in enterohemorrhagic Escherichia coli strains of O157 and non-O157 serotypes","volume":"8","author":"Ogura","year":"2007","journal-title":"Genome Biol"},{"issue":"9","key":"10.1002\/lsm.21069-BIB16|cit16","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1128\/AAC.00006-08","article-title":"Inhibitors of bacterial multidrug efflux pumps potentiate antimicrobial photoinactivation","volume":"52","author":"Tegos","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"10.1002\/lsm.21069-BIB17|cit17","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1096\/fj.02-0088com","article-title":"Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: Implications for drug and gene delivery","volume":"16","author":"Panyam","year":"2002","journal-title":"FASEB J"},{"issue":"12","key":"10.1002\/lsm.21069-BIB18|cit18","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1007\/s11095-005-8343-0","article-title":"Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: Part 2. In vivo distribution and tumor localization studies","volume":"22","author":"Shenoy","year":"2005","journal-title":"Pharm Res"},{"issue":"4","key":"10.1002\/lsm.21069-BIB19|cit19","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00280-006-0287-5","article-title":"Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: Part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model","volume":"59","author":"Devalapally","year":"2007","journal-title":"Cancer Chemother Pharmacol"},{"issue":"3-4","key":"10.1002\/lsm.21069-BIB20|cit20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0928-0987(03)00017-4","article-title":"Enhanced photodynamic activity of meso-tetra(4-hydroxyphenyl)porphyrin by incorporation into sub-200\u2009nm nanoparticles","volume":"18","author":"Konan","year":"2003","journal-title":"Eur J Pharm Sci"},{"issue":"1-2","key":"10.1002\/lsm.21069-BIB21|cit21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ijpharm.2005.10.048","article-title":"Zinc(II) phthalocyanine loaded PLGA nanoparticles for photodynamic therapy use","volume":"310","author":"Ricci-Junior","year":"2006","journal-title":"Int J Pharm"},{"issue":"12","key":"10.1002\/lsm.21069-BIB22|cit22","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1021\/nl0519229","article-title":"Polymeric nanoparticle preparation that eradicates tumors","volume":"5","author":"McCarthy","year":"2005","journal-title":"Nano Lett"},{"issue":"2","key":"10.1002\/lsm.21069-BIB23|cit23","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.joen.2009.10.011","article-title":"Nanoparticle-based endodontic antimicrobial photodynamic therapy","volume":"36","author":"Pagonis","year":"2010","journal-title":"J Endod"},{"issue":"3","key":"10.1002\/lsm.21069-BIB24|cit24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/1011-1344(95)07148-2","article-title":"Photoinactivation of bacteria. Use of a cationic water-soluble zinc phthalocyanine to photoinactivate both gram-negative and gram-positive bacteria","volume":"32","author":"Minnock","year":"1996","journal-title":"J Photochem Photobiol B"},{"issue":"3","key":"10.1002\/lsm.21069-BIB25|cit25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/1011-1344(95)07147-4","article-title":"Meso-substituted cationic porphyrins as efficient photosensitizers of gram-positive and gram-negative bacteria","volume":"32","author":"Merchat","year":"1996","journal-title":"J Photochem Photobiol B"},{"issue":"10","key":"10.1002\/lsm.21069-BIB26|cit26","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1128\/AAC.42.10.2595","article-title":"Targeted antimicrobial photochemotherapy","volume":"42","author":"Soukos","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"10.1002\/lsm.21069-BIB27|cit27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/mp0500420","article-title":"Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. 1. In vitro evaluations","volume":"2","author":"Shenoy","year":"2005","journal-title":"Mol Pharm"},{"key":"10.1002\/lsm.21069-BIB28|cit28","volume-title":"Design and analysis of clinical experiments","author":"Fleiss","year":"1986"},{"issue":"8","key":"10.1002\/lsm.21069-BIB29|cit29","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1166\/jnn.2004.130","article-title":"Cationic poly(lactide-co-glycolide) nanoparticles as efficient in vivo gene transfection agents","volume":"4","author":"Kumar","year":"2004","journal-title":"J Nanosci Nanotechnol"},{"issue":"1-2","key":"10.1002\/lsm.21069-BIB30|cit30","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ijpharm.2007.07.041","article-title":"Adhesion of PLGA or Eudragit\/PLGA nanoparticles to Staphylococcus and Pseudomonas","volume":"349","author":"Dillen","year":"2008","journal-title":"Int J Pharm"},{"issue":"2","key":"10.1002\/lsm.21069-BIB31|cit31","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/bip.10585","article-title":"Amphipathic peptides and drug delivery","volume":"76","author":"Fernandez-Carneado","year":"2004","journal-title":"Biopolymers"},{"issue":"1","key":"10.1002\/lsm.21069-BIB32|cit32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1600-0722.2007.00418.x","article-title":"Efficacy of gasiform ozone and photodynamic therapy on a multispecies oral biofilm in vitro","volume":"115","author":"Muller","year":"2007","journal-title":"Eur J Oral Sci"},{"issue":"5","key":"10.1002\/lsm.21069-BIB33|cit33","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1399-302X.2007.00366.x","article-title":"Antibiotic resistance in an in vitro subgingival biofilm model","volume":"22","author":"Sedlacek","year":"2007","journal-title":"Oral Microbiol Immunol"},{"issue":"1","key":"10.1002\/lsm.21069-BIB34|cit34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/26.1.1","article-title":"The biofilm glycocalyx as a resistance factor","volume":"26","author":"Hoyle","year":"1990","journal-title":"J Antimicrob Chemother"},{"key":"10.1002\/lsm.21069-BIB35|cit35","first-page":"177","article-title":"Biofilms, antibiotics and penetration","volume":"2","author":"Nichols","year":"1991","journal-title":"Rev Med Microbiol"},{"issue":"4","key":"10.1002\/lsm.21069-BIB36|cit36","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1128\/AAC.32.4.518","article-title":"Inhibition of tobramycin diffusion by binding to alginate","volume":"32","author":"Nichols","year":"1988","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.21069","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/lsm.21069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T15:42:00Z","timestamp":1625499720000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.21069"}},"subtitle":["PHOTODESTRUCTION OF ORAL BACTERIA"],"short-title":[],"issued":{"date-parts":[[2011,8,23]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,9]]}},"URL":"https:\/\/doi.org\/10.1002\/lsm.21069","archive":["Portico"],"relation":{},"ISSN":["0196-8092"],"issn-type":[{"value":"0196-8092","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8,23]]}}}