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However, available literature is scarce regarding the treatment of Nevus of Ota in skin types darker than IV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We report about four Fitzpatrick phototype V patients treated for Nevus of Ota with a q\u2010switched Nd:YAG laser at 1,064\u2009nm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four patients with Fitzpatrick phototype V were treated for Nevus of Ota with a q\u2010switched Nd:YAG laser at 1,064\u2009nm in a private practice setting. Pulse diameter for the treatments was 2\u2009mm and pulses were applied typically in a non\u2010overlapping fashion. Treatment energies ranged from 4.1 to 9.5\u2009J\/cm<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All four patients of this case series showed significant cosmetic improvement. Improvement ratings, based upon pre\u2010 and post\u2010treatment photographs rated by blinded investigators, were in between 6 and 10 with a mean of 8.5 on a 10\u2010point scale. Side effects were mostly short termed and typical for this laser technique. No post\u2010inflammatory hyperpigmentation was observed however one case of permanent drop\u2010like hypopigmentation was encountered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A 1,064\u2009nm q\u2010switched Nd:YAG laser treatment could be an effective and reasonably safe treatment for patients with Nevus of Ota and Fitzpatrick skin type V. Patients should be counselled before treatment regarding the risk of permanent hypopigmentation. Lasers Surg. 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