{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:14:14Z","timestamp":1792642454737,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T00:00:00Z","timestamp":1321920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>We report the final results of a pilot clinical trial exploring the safety and feasibility of real\u2010time magnetic resonance\u2010guided laser\u2010induced thermal therapy (MRgLITT) for treatment of resistant focal metastatic intracranial tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>In patients with chemotherapy, whole\u2010brain radiation, and radiosurgery resistant metastatic intracranial tumors, minimally invasive stereotaxic placement of a saline\u2010cooled interstitial fiberoptic laser applicator under local anesthesia was followed by laser irradiation during continuous magnetic resonance imaging (MRI) scanning. A computer workstation extracted real\u2010time temperature\u2010sensitive information for feedback control over laser delivery. A total of 15 metastatic tumors were treated in 7 patients. Patients were followed with physical exam and imaging for 30 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all cases, the procedure was well tolerated, and patients were discharged home within 24\u2009hours. Follow\u2010up imaging at up to 30 months showed an acute increase in apparent lesion volume followed by a gradual and steady decrease. No tumor recurrence within thermal ablation zones was noted. Kaplan\u2013Meier analysis indicated that the median survival was 19.8 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Real\u2010time magnetic resonance (MR) guidance of laser\u2010induced thermal therapy (LITT) offers a high level of control. This tool therefore enables a minimally invasive option for destruction and treatment of resistant focal metastatic intracranial tumors. MR\u2010guided LITT appears to provide a safe and potentially effective treatment for recurrent focal metastatic brain disease. A larger phase II and III series would be of interest to quantify potential median survival advantage. Lasers Surg. Med. 43:943\u2013950, 2011. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.21138","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T20:47:47Z","timestamp":1321994867000},"page":"943-950","source":"Crossref","is-referenced-by-count":203,"title":["Laser thermal therapy: Real\u2010time MRI\u2010guided and computer\u2010controlled procedures for metastatic brain tumors"],"prefix":"10.1002","volume":"43","author":[{"given":"Alexandre","family":"Carpentier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J.","family":"McNichols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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