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The device consisted of two 2.6\u2009mm diameter reservoirs containing 10% Na fluorescein dye. The device was implanted in the rabbit's eye (<jats:italic>n<\/jats:italic>\u2009=\u20092) with the cap of the device facing toward the exterior of the eye. Once the animals recovered from the implant surgery, 100% anhydrous glycerol was topically applied to the eye at the implantation site to decrease light scattering in the conjunctiva and sclera. The dye was released from one of the reservoir either using a 28\u2009G \u00bd needle or an ophthalmic Q\u2010switched Nd:YAG laser. A fluorescence spectrophotometer (FS) with fiber optic probe was used to measure the half\u2010life of the dye in the eye. Measurements of fluorescence intensity were collected until the measurements return to baseline and histology was done on the tissue surrounded the device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the devices leaked of 10% Na fluorescein dye after implant. The ablation threshold of the drug delivery device was between 6 and 10\u2009mJ to create 100\u2013500\u2009\u00b5m holes. The half\u2010life measurement of the dye was found to be 13 days at the vitreous chamber after measuring the fluorescence intensity through the dilated cornea. Histology study showed minimal immune and foreign body response such as mild inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study established that the drug delivery device seemed to elicit minimal inflammatory response and retained its fluidic content until it was released with relatively longer retention time (half\u2010life). Thus, similar device could be used for controlled release of drugs for certain ocular diseases. Lasers Surg. 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