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Patients were placed in the following groups: Group SRP\u2014scaling and root planning with an ultrasonic device (SRP); and Group SRP\u2009+\u2009PDT\u2014SRP associated with a course of PDT with a diode laser with a wavelength of 660\u2009nm and 0.03\u2009W power associated with methylene blue 0.01% lasting 133\u2009seconds. All clinical measurements (periodontal probing depth (PPD), gingival recession (GR), clinical attachment level (CAL), full\u2010mouth plaque index (FMPI), bleeding score (FMBS)), and microbiological parameters (detection of <jats:italic>Porphyromonas gingivalis<\/jats:italic> (Pg), <jats:italic>Tannerella forsythia<\/jats:italic> (Tf), and <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> (Aa)) were assessed at baseline and at 45 days, and 3 and 6 months after therapy. The ANOVA\/Tukey was used for statistical analysis (<jats:italic>\u03b1<\/jats:italic>\u2009=\u20095%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no differences in any of the investigated parameters observed at baseline in the two groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Moreover, participants in the SRP\u2009+\u2009PDT group presented a higher PPD reduction and CAL gain than those in the SRP group at 45 days and 3 and 6 months. At 6 months, sites receiving SRP\u2009+\u2009PDT showed a significant PPD reduction of 1.4\u2009\u00b1\u20090.5\u2009mm, while those in the SRP group showed a 0.3\u2009\u00b1\u20090.8\u2009mm reduction (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The CAL gain at the sixth month was 1.3\u2009\u00b1\u20090.5\u2009mm and 0.2\u2009\u00b1\u20090.7\u2009mm for participants in the SRP\u2009+\u2009PDT and SRP groups, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Microbiologically, both therapies presented a reduction in the detection of Pg, Tf, and Aa, and there was no difference between them (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We concluded that PDT therapy used adjunctively to SRP could promote additional benefits in the treatment of HIV\u2010associated periodontitis. Lasers Surg. Med. 44:296\u2013302, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22016","type":"journal-article","created":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T17:23:04Z","timestamp":1331140984000},"page":"296-302","source":"Crossref","is-referenced-by-count":52,"title":["PDT in non\u2010surgical treatment of periodontitis in HIV patients: A split\u2010mouth, randomized clinical trial"],"prefix":"10.1002","volume":"44","author":[{"given":"Gilberto A.","family":"Noro Filho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato C.V.","family":"Casarin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio Z.","family":"Casati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elcio 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