{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:36:05Z","timestamp":1783694165054,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>A smooth corneal surface prior to laser ablation is important in order to achieve a favorable refractive outcome. In this study, we compare PRK outcomes following two commonly used methods of epithelial debridement: Amoils epithelial scrubber (brush) versus 20% ethanol (alcohol).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Patients and Methods<\/jats:title><jats:p>We reviewed records of patients who underwent wavefront\u2010optimized PRK for myopia or myopic astigmatism between January 2008 and June 2010. Two treatment groups (brush vs. alcohol) were compared in terms of uncorrected distance visual acuity (UDVA), manifest refraction spherical equivalent (MRSE), corrected distance visual acuity (CDVA), and complications at postoperative months 1, 3, 6, and 12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One thousand five hundred ninety\u2010three eyes of 804 patients underwent PRK during the study period: 828 brush\u2010treated eyes and 765 alcohol\u2010treated eyes. At 6 months postoperatively UDVA was \u226520\/20 in 94.7% of brush\u2010treated eyes versus 94.4% of alcohol\u2010treated eyes (<jats:italic>P<\/jats:italic>\u2009=\u20090.907). At 1 month a higher percentage of brush\u2010treated eyes maintained or gained one or more lines CDVA compared to alcohol\u2010treated eyes (<jats:italic>P<\/jats:italic>\u2009=\u20090.007), but there were no other differences in UDVA, MRSE, or CDVA at any point postoperatively. At 1 month 75.4% of brush\u2010treated eyes versus 70.4% of alcohol\u2010treated eyes were free of complications (<jats:italic>P<\/jats:italic>\u2009=\u20090.032), and there were fewer brush\u2010treated eyes with corneal haze (4.0% vs. 6.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.012) and dry eye (8.9% vs. 14.4%, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). Although corneal haze was slightly more frequent in the alcohol group, most was trace and not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although alcohol\u2010assisted PRK had more minor complications in the early postoperative period, including corneal haze and dry eye, results for both groups beyond 1 month were comparable. Lasers Surg. Med. 44: 475\u2013481, 2012. \u00a9 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22036","type":"journal-article","created":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T12:31:43Z","timestamp":1338553903000},"page":"475-481","source":"Crossref","is-referenced-by-count":11,"title":["Alcohol versus brush PRK: Visual outcomes and adverse effects"],"prefix":"10.1002","volume":"44","author":[{"given":"Rose K.","family":"Sia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise S.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Stutzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Psolka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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