{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:02Z","timestamp":1786978202967,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:00:00Z","timestamp":1339459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cervical intraepithelial neoplasia (CIN) 1\u20133 is the precursor of invasive cervical cancer and associated with human papillomavirus infection. Standard treatment is surgical and may be associated with subsequent pregnancy complications. Photodynamic therapy (PDT) of CIN may be an interesting alternative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Patients were treated by PDT using hexaminolevulinate (HAL) and methylaminolevulinate in six dose and light groups and two incubation periods in a double\u2010blind setting. Follow\u2010up examinations were performed after 3, 6, and 12 months with histology, cytology, and HPV testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included eight patients with CIN1, 23 with CIN2, and 36 with CIN3. Treatment was well tolerated. HAL 40\u2009mM with 3\u2010hour application turned out to be the most\u2010effective group with 67% (10\/15) complete response rate. The combined complete and partial response for patients with CIN2 was 83% (20\/24).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PDT with CIN may be a safe and effective procedure for CIN treatment. Lasers Surg. Med. 44: 468\u2013474, 2012. \u00a9 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.22041","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T08:17:22Z","timestamp":1339489042000},"page":"468-474","source":"Crossref","is-referenced-by-count":36,"title":["Photodynamic therapy of cervical intraepithelial neoplasia 1\u20133 and human papilloma virus (HPV) infection with methylaminolevulinate and hexaminolevulinate\u2014A double\u2010blind, dose\u2010finding study"],"prefix":"10.1002","volume":"44","author":[{"given":"Philipp","family":"Soergel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunn 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