{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:18:24Z","timestamp":1790068704413,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T00:00:00Z","timestamp":1341446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The treatment of acne scars with fractional CO<jats:sub>2<\/jats:sub> lasers is gaining increasing impact, but has so far not been compared side\u2010by\u2010side to untreated control skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>In a randomized controlled study to examine efficacy and adverse effects of fractional CO<jats:sub>2<\/jats:sub> laser resurfacing for atrophic acne scars compared to no treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients (<jats:italic>n<\/jats:italic>\u2009=\u200913) with atrophic acne scars in two intra\u2010individual areas of similar sizes and appearances were randomized to (i) three monthly fractional CO<jats:sub>2<\/jats:sub> laser treatments (MedArt 610; 12\u201314\u2009W, 48\u201356\u2009mJ\/pulse, 13% density) and (ii) no treatment. Blinded on\u2010site evaluations were performed by three physicians on 10\u2010point scales. Endpoints were change in scar texture and atrophy, adverse effects, and patient satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preoperatively, acne scars appeared with moderate to severe uneven texture (6.15\u2009\u00b1\u20091.23) and atrophy (5.72\u2009\u00b1\u20091.45) in both interventional and non\u2010interventional control sites, <jats:italic>P<\/jats:italic>\u2009=\u20091. Postoperatively, lower scores of scar texture and atrophy were obtained at 1 month (scar texture 4.31\u2009\u00b1\u20091.33, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001; atrophy 4.08\u2009\u00b1\u20091.38, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), at 3 months (scar texture 4.26\u2009\u00b1\u20091.97, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001; atrophy 3.97\u2009\u00b1\u20092.08, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), and at 6 months (scar texture 3.89\u2009\u00b1\u20091.7, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001; atrophy 3.56\u2009\u00b1\u20091.76, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Patients were satisfied with treatments and evaluated scar texture to be mild or moderately improved. Adverse effects were minor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this single\u2010blinded randomized controlled trial we demonstrated that moderate to severe atrophic acne scars can be safely improved by ablative fractional CO<jats:sub>2<\/jats:sub> laser resurfacing. The use of higher energy levels might have improved the results and possibly also induced significant adverse effects. Lasers Surg. Med. 44: 447\u2013452, 2012. \u00a9 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22048","type":"journal-article","created":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T15:38:03Z","timestamp":1341502683000},"page":"447-452","source":"Crossref","is-referenced-by-count":83,"title":["Fractional CO<sub>2<\/sub> laser resurfacing for atrophic acne scars: A randomized controlled trial with blinded response evaluation"],"prefix":"10.1002","volume":"44","author":[{"given":"Lene","family":"Hedelund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina S.","family":"Haak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine","family":"Togsverd\u2010Bo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten K.","family":"Bogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bjerring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete","family":"H\u00e6dersdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.05.029"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/14764170310001258"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113451"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.33030.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2002.01319.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1996.tb00497.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.08126.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1999)24:2<87::AID-LSM3>3.0.CO;2-P"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.4.391"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2001.01015.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200201000-00048"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20254"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.01.003"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20048"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20659"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/14764171003706166"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20725"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01316.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20974"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03551.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01803.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1586\/erd.10.74"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20405"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1117\/1.3275479"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20715"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/14764170903356465"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-010-0829-2"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22048","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.22048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T05:41:50Z","timestamp":1698644510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.22048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,5]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1002\/lsm.22048"],"URL":"https:\/\/doi.org\/10.1002\/lsm.22048","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,5]]}}}