{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:46:10Z","timestamp":1790322370743,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T00:00:00Z","timestamp":1355875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melasma is a common acquired symmetrical hyperpigmentation that is often recurrent and refractory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the efficacy and safety of a single administration of high\u2010density fractional thulium fiber laser (1,927\u2009nm) for the treatment of refractory melasma in 20 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A retrospective chart and photographs review of 20 women (Fitzpatrick skin type II\u2013IV) with clinical diagnosis of melasma treated with the 1,927\u2010nm fractionated thulium laser at 10 or 20\u2009mJ\/cm<jats:sup>2<\/jats:sup>, with 60\u201370% surface area coverage. Four investigators independently evaluated Melasma Area Severity Index (MASI) scores before, 4 weeks, 3\u20136 months, and 6\u201312 months after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean MASI scores decreased dramatically from 13.2\u2009\u00b1\u20095.4 before treatment to 8.5\u2009\u00b1\u20093.5 at 4 weeks after laser treatment (<jats:italic>P<\/jats:italic>\u2009=\u20090.004). Patient assessment revealed that 12 of the 20 subjects had more than 50% clearance of their melasma. Recurrence was reported by 7 out of 15 patients who were successfully followed\u2010up (mean 10.2 months). Two patients developed postinflammatory hyperpigmentation that subsided with topical bleaching after 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010density coverage fractional 1,927\u2010nm thulium laser proved to be safe and effective for melasma with long\u2010term remission. Lasers Surg. Med. 45: 95\u2013101, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22100","type":"journal-article","created":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T14:01:29Z","timestamp":1355925689000},"page":"95-101","source":"Crossref","is-referenced-by-count":57,"title":["Treatment of melasma with the 1,927\u2010nm fractional thulium fiber laser: A retrospective analysis of 20 cases with long\u2010term follow\u2010up"],"prefix":"10.1002","volume":"45","author":[{"given":"Ane Beatriz M.","family":"Niwa Massaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasima","family":"Eimpunth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina 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