{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:20:30Z","timestamp":1776468030922,"version":"3.51.2"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T00:00:00Z","timestamp":1363564800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Cellulite is present in 90% of post\u2010adolescent women. Several technologies have been developed for treating cellulite; however, they all involve some degree of massage or mechanical manipulation. The purpose of this study was to assess the effectiveness of a low\u2010level laser light device employing green 532\u2009nm diodes as a stand\u2010alone procedure without massage or mechanical manipulation for improving the appearance of cellulite in the thighs and buttocks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>This double\u2010blind study randomized subjects to undergo treatment with the LLLT device (<jats:italic>N<\/jats:italic>\u2009=\u200934) or sham treatment (<jats:italic>N<\/jats:italic>\u2009=\u200934). During a 2\u2010week treatment phase, each subject received three weekly treatment sessions 2\u20133 days apart. During each session, the front and back of the hips, thighs, and waist were exposed for 15\u2009minutes (30\u2009minutes total).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen subjects in the LLLT group achieved a decrease of one or more stages on the Nurnberger\u2013Muller grading scale (55.88%) versus three subjects (8.82%) in the sham\u2010treated group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Two LLLT\u2010treated subjects achieved 2\u2010stage improvements on the Nurnberger\u2013Muller Scale at the 2\u2010week study endpoint and four did at the 6\u2010week follow\u2010up evaluation versus none of the sham\u2010treated subjects at either time point. Subjects treated with LLLT achieved a significant decrease in combined baseline thigh circumference at the 2\u2010week study endpoint and 6\u2010week follow\u2010up evaluation (for each, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001 vs. baseline) versus no change for sham\u2010treated subjects. LLLT\u2010treated subjects also showed significant decreases in mean baseline body weight (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0005), BMI (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and percent BSA affected by cellulite (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0005) versus no change for any parameter among sham\u2010treated subjects. Most LLLT\u2010treated subjects (62.1%) were Very Satisfied or Somewhat Satisfied with the improvement in cellulite they received versus 25.8% of sham\u2010treated subjects. There were no reports of adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low\u2010level laser therapy using green 532\u2009nm diodes is safe and effective for improving the appearance of cellulite in the thighs and buttocks. In contrast with other technologies, LLLT is effective as a stand\u2010alone procedure without requiring massage or mechanical manipulation. Future studies will assess the long\u2010term benefits of LLLT for the treatment of cellulite. Lasers Surg. Med. 45: 141\u2013147, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22119","type":"journal-article","created":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T13:52:14Z","timestamp":1363614734000},"page":"141-147","source":"Crossref","is-referenced-by-count":46,"title":["A double\u2010blind, placebo\u2010controlled randomized trial evaluating the ability of low\u2010level laser therapy to improve the appearance of cellulite"],"prefix":"10.1002","volume":"45","author":[{"given":"Robert F.","family":"Jackson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory C.","family":"Roche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven 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