{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:38:19Z","timestamp":1779233899947,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T00:00:00Z","timestamp":1370390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["30972665"],"award-info":[{"award-number":["30972665"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["81272990"],"award-info":[{"award-number":["81272990"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation Grant of Shanghai","award":["11ZR1432800"],"award-info":[{"award-number":["11ZR1432800"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Extramammary Paget's disease (EMPD) is a rare intra\u2010epithelial neoplasm. Surgical excision is the treatment of choice. The usefulness of topical photodynamic therapy (PDT) in the treatment of EMPD has been reported. The objective of this prospective pilot study was to investigate the feasibility of combined PDT and surgery in the treatment of EMPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>A total of 13 patients with 19 large EMPD lesions were recruited and assigned to surgery (<jats:italic>n<\/jats:italic>\u2009=\u20095) or PDT\u2009+\u2009surgery (<jats:italic>n<\/jats:italic>\u2009=\u20098) group. For the PDT\u2009+\u2009surgery group, four sessions of topical PDT mediated with 20% 5\u2010aminolevulinic acid (ALA\u2010PDT) were applied prior to surgery. Patients were followed up for 12 months. Treatment outcomes, adverse reactions and recurrence were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the surgery group, recurrence was seen in 2 out of 8 lesions (25%). In the combination group, over 58% reduction in lesion size was achieved after 4\u2010sessions of PDT and recurrence was seen in 1 out of 11 lesions (9.1%) after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Multiple ALA\u2010PDT could be applied to reduce the severity of EMPD lesion and improve the success of surgery. Lasers Surg. Med. 45:296\u2013301, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22142","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T04:52:20Z","timestamp":1370494340000},"page":"296-301","source":"Crossref","is-referenced-by-count":43,"title":["A prospective pilot study to evaluate combined topical photodynamic therapy and surgery for extramammary paget's disease"],"prefix":"10.1002","volume":"45","author":[{"given":"Hong\u2010wei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Shanghai Skin Diseases Hospital 200 Wuyi Road Shanghai P.R. China"},{"name":"Department of Dermatology Shanghai Huadong Hospital Shanghai P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Shanghai Skin Diseases Hospital 200 Wuyi Road Shanghai P.R. 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