{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:34:54Z","timestamp":1788870894392,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T00:00:00Z","timestamp":1378684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006286","name":"Aage Bangs Fond","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006286","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Treatment of acne scars with ablative fractional CO\n 2<\/jats:sub>\n laser appears to be an effective and well\u2010tolerated treatment. However, so far the influence of treatment interval has not been evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To evaluate whether treatment of acne scars with fractional CO\n 2<\/jats:sub>\n laser resurfacing at 1\u2010month interval achieves better results with no difference in the occurrence of adverse effects, than treatment given at 3\u2010months interval.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients (\n n<\/jats:italic>\n \u2009=\u200913) with symmetrical atrophic acne scars on right and left sides of the mid\u2010face and lower\u2010face were randomized to two fractional CO\n 2<\/jats:sub>\n laser treatments at 1\u2010month versus 3\u2010month intervals. Blinded on\u2010site evaluations were performed 1 and 6 months after the last treatment on 10\u2010point scales. Endpoints were scar atrophy, patient satisfaction, and adverse effects.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Pre\u2010operatively, acne scars were moderately atrophic (5.86\u2009\u00b1\u20091.87). After treatment acne scars appeared with less atrophy on both treated sides 1 month postoperatively (1\u2010month interval 1.96\u2009\u00b1\u20091.23,\n P<\/jats:italic>\n \u2009<\u20090.0001; 3\u2010months interval 1.82\u2009\u00b1\u20091.08,\n P<\/jats:italic>\n \u2009=\u20090.0006) and 6 months postoperatively (1\u2010month interval 1.56\u2009\u00b1\u20091.24,\n P<\/jats:italic>\n \u2009=\u20090.0021; 3\u2010months interval 1.33\u2009\u00b1\u20091.66,\n P<\/jats:italic>\n \u2009=\u20090.0002). The treatment interval did not influence the improvement of scar atrophy at any time postoperatively (\n P<\/jats:italic>\n \u2009=\u20090.81). Patients were moderately and equally satisfied with the treatment result on facial sides (\n P<\/jats:italic>\n \u2009=\u20090.93). Postoperative adverse effects were minor and not influenced by the treatment interval.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Fractional CO\n 2<\/jats:sub>\n laser resurfacing improves atrophic acne scars and a treatment interval of either 1\u2010month or 3\u2010months does not seem to influence the improvement of scar atrophy nor the occurrence of postoperative adverse effects. Lasers Surg. Med. 46:89\u201393, 2014. \u00a9 2013 Wiley Periodicals, Inc.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/lsm.22165","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T03:32:50Z","timestamp":1378697570000},"page":"89-93","source":"Crossref","is-referenced-by-count":30,"title":["Treatment of acne scars with fractional CO\n 2<\/sub>\n laser at 1\u2010month versus 3\u2010month intervals: An intra\u2010individual randomized controlled trial"],"prefix":"10.1002","volume":"46","author":[{"given":"Marie","family":"Bj\u00f8rn","sequence":"first","affiliation":[{"name":"Department of Dermatology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte","family":"Stausb\u00f8l\u2010Gr\u00f8n","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Braae Olesen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Hedelund","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170310001258"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.05.029"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12103"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12030"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22048"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.01999.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-010-0801-1"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01513.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03551.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20796"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01193.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20725"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.08.051"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20659"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.699679"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-012-1120-5"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22165","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.22165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:35:12Z","timestamp":1696322112000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.22165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,9]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1002\/lsm.22165"],"URL":"https:\/\/doi.org\/10.1002\/lsm.22165","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,9]]}}}