{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:59:09Z","timestamp":1785859149989,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ClinicalTrials.gov Identifier","award":["NCT01437163"],"award-info":[{"award-number":["NCT01437163"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Low level laser therapy (LLLT) has been used to promote hair growth. A double\u2010blind randomized controlled trial was undertaken to define the safety and physiologic effects of LLLT on males with androgenic alopecia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010four males (18\u201348 yo, Fitzpatrick I\u2013IV, Hamilton\u2013Norwood IIa\u2013V) were recruited. A transition zone scalp site was selected; hairs were trimmed to 3\u2009mm height; the area was tattooed and photographed. The active group received a \u201cTOPHAT655\u201d unit containing 21, 5\u2009mW lasers (655\u2009\u00b1\u20095\u2009nm), and 30 LEDS (655\u2009\u00b1\u200920\u2009nm), in a bicycle\u2010helmet like apparatus. The placebo group unit appeared identical, containing incandescent red lights. Patients treated at home every other day\u2009\u00d7\u200916 weeks (60 treatments, 67.3\u2009J\/cm<jats:sup>2<\/jats:sup> irradiance\/25\u2009minute treatment), with follow up and photography at 16 weeks. A masked 2.85\u2009cm<jats:sup>2<\/jats:sup> photographic area was evaluated by another blinded investigator. The primary endpoint was the percent increase in hair counts from baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010one patients completed the study (22 active, 19 placebo). No adverse events or side effects were reported. Baseline hair counts were 162.7\u2009\u00b1\u200995.9 (<jats:italic>N<\/jats:italic>\u2009=\u200922) in placebo and 142.0\u2009\u00b1\u200973.0 (<jats:italic>N<\/jats:italic>\u2009=\u200922) and active groups respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.426). Post Treatment hair counts were 162.4\u2009\u00b1\u200962.5 (<jats:italic>N<\/jats:italic>\u2009=\u200919) and 228.7\u2009\u00b1\u2009102.8 (<jats:italic>N<\/jats:italic>\u2009=\u200922), respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.0161). A 39% percent hair increase was demonstrated (28.4\u2009\u00b1\u200946.2 placebo, <jats:italic>N<\/jats:italic>\u2009=\u200919; 67.2\u2009\u00b1\u200933.4, active, <jats:italic>N<\/jats:italic>\u2009=\u200922) (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) Deleting one placebo group subject with a very high baseline count and a very large decrease, resulted in baseline hair counts of 151.1\u2009\u00b1\u200981.0 (<jats:italic>N<\/jats:italic>\u2009=\u200921) and 142.0\u2009\u00b1\u200973.0 (<jats:italic>N<\/jats:italic>\u2009=\u200922), respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.680). Post treatment hair counts were 158.2\u2009\u00b1\u200961.5 (<jats:italic>N<\/jats:italic>\u2009=\u200918) and 228.7\u2009\u00b1\u2009102.8 (<jats:italic>N<\/jats:italic>\u2009=\u200922) (<jats:italic>P<\/jats:italic>\u2009=\u20090.011), resulting in a 35% percent increase in hair growth (32.3\u2009\u00b1\u200944.2, placebo, <jats:italic>N<\/jats:italic>\u2009=\u200918; 67.2\u2009\u00b1\u200933.4, active, <jats:italic>N<\/jats:italic>\u2009=\u200922) (<jats:italic>P<\/jats:italic>\u2009=\u20090.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LLLT of the scalp at 655\u2009nm significantly improved hair counts in males with androgenetic alopecia. Lasers Surg. Med. 45:487\u2013495, 2013. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22173","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T05:47:34Z","timestamp":1444715254000},"page":"487-495","source":"Crossref","is-referenced-by-count":144,"title":["The growth of human scalp hair mediated by visible red light laser and LED sources in males"],"prefix":"10.1002","volume":"45","author":[{"given":"Raymond J.","family":"Lanzafame","sequence":"first","affiliation":[{"name":"Raymond J. Lanzafame MD PLLC Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond R.","family":"Blanche","sequence":"additional","affiliation":[{"name":"NST Consulting LLC Chatham New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam B.","family":"Bodian","sequence":"additional","affiliation":[{"name":"Bodian Dermatology Group PC Great Neck New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Chiacchierini","sequence":"additional","affiliation":[{"name":"R.P. Chiacchierini &amp; Associates Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Fernandez\u2010Obregon","sequence":"additional","affiliation":[{"name":"Hudson Dermatology &amp; Skin Cancer Center Hoboken New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Kazmirek","sequence":"additional","affiliation":[{"name":"Kaz Arts Photography Bridgewater New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,19]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"571","volume-title":"Laser Therapy. 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