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Topical therapies have less serious side effects, yet provide only limited efficacy due to their inability to penetrate the nail plate. These limitations have led to the investigation of laser and light\u2010based modalities as alternative treatment options for onychomycosis. This article will provide an overview and critical assessment of the field of laser and other energy\u2010based treatments for onychomycosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>A literature search was conducted on laser and light\u2010based treatments for onychomycosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Early data are promising, however, many of these studies are small or poorly designed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Further evaluation and larger studies are needed to determine the optimal light source, pulse duration, and treatment schedule for long\u2010term success. Lasers Surg. 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