{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:38:18Z","timestamp":1779233898655,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T00:00:00Z","timestamp":1388966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Scarring is a very common complication of severe acne and is difficult to treat by conventional methods. 5\u2010Aminolevulinic acid (ALA) photodynamic therapy (PDT) is a novel treatment for improving acne lesions. Fractional laser resurfacing is a promising treatment for scar treatment because of its unique ability to stimulate the wound healing response and its depth of penetration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of combination therapies of ALA\u2010PDT and ablative fractional Er:YAG laser (2,940\u2009nm) for scarring lesions in severe acne patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, single\u2010arm, pilot study. Forty subjects with severe acne were treated with 15% ALA\u2010PDT for four times at 10\u2010day intervals. They then received ablative fractional Er:YAG laser treatment five times at 4\u2010week intervals. Three independent investigators evaluated subject outcomes at 1, 3, 6, and 12 months post\u2010treatment (primary outcome); patients also provided self\u2010assessments of improvement (secondary outcome).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant reductions in acne score (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) were obtained at follow\u2010up visits after 1, 3, 6, and 12 months. After 6 month, the lesions showed overall improvement in all of subjects (good to excellent in acne inflammatory lesions), 80% overall improvement in acne scars. After 12 months, most of subjects had improved hypertrophic\/atrophic scars (good to excellent in 85%) and no one had recurrent acne inflammatory lesions. Patient self\u2010evaluation also revealed good to excellent improvements (on average) in acne lesions and scarring, with significant improvements in self\u2010esteem after 6 months post\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PDT can control the inflammation and improve the severity of acne lesions. Fractional resurfacing is a promising new treatment modality for scars by stimulating wound healing and remodeling. The combination therapy is a promising option for severe acne to prevent and improve car formation. Lasers Surg. Med. 46:165\u2013172, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22219","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T07:41:06Z","timestamp":1388994066000},"page":"165-172","source":"Crossref","is-referenced-by-count":36,"title":["Combination ALA\u2010PDT and ablative fractional Er:YAG laser (2,940\u2009nm) on the treatment of severe acne"],"prefix":"10.1002","volume":"46","author":[{"given":"Rui","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Dermatology Southwest Hospital Third Military Medical University Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Southwest Hospital Third Military Medical University Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Southwest Hospital Third Military Medical University Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Southwest Hospital Third Military Medical University Chongqing 400038 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Hamblin","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine Massachusetts General Hospital Boston MA 02114"},{"name":"Department of Dermatology Harvard Medical School Boston MA 02115"},{"name":"Harvard\u2010MIT Division of Health Sciences and Technology Cambridge MA 02139"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.056"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09860.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00046.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04013.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02503.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.019"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.00932.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01258.x"},{"issue":"3","key":"e_1_2_6_11_1","first-page":"294","article-title":"Ablative fractional laser resurfacing for the treatment of a third\u2010degree burn","volume":"8","author":"Waibel J","year":"2009","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_12_1","volume-title":"A manual of cutaneous medicine","author":"Pillsbury DMSW","year":"1961"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20607"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34204.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-008-0545-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170310001258"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.057"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20879"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.01.003"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02009.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01316.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.08.051"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22038"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.248"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2012.39.3.232"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(96)07291-0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(03)00050-0"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1998.tb04161.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.10012"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22219","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.22219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T01:18:09Z","timestamp":1696382289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.22219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,6]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1002\/lsm.22219"],"URL":"https:\/\/doi.org\/10.1002\/lsm.22219","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,6]]}}}