{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:56:25Z","timestamp":1788184585849,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T00:00:00Z","timestamp":1388966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>There is an increasing interest in treating vascular lesions with a long\u2010pulse Alexandrite laser. However, it is difficult to search information in the literature about infantile hemangiomas (IH) treated with long\u2010pulse Alexandrite laser. This article aims to determine whether 755\u2009nm long\u2010pulse Alexandrite laser is effective and safe for early intervention of IH and provides some new data on this issue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This is a retrospective study of 48 infants with IH treated with long\u2010pulse Alexandrite laser during a 1.5\u2010year period. Patients received a series of 1\u20137 treatment sessions with long\u2010pulse Alexandrite laser at settings of 3\u2009milliseconds pulse duration, 6\u20138\u2009mm spot, 45\u201370\u2009J\/cm<jats:sup>2<\/jats:sup>fluences, and with dynamic cooling device (DCD) spray duration of 90\u2009milliseconds and delay of 80\u2009milliseconds, given at 4\u2010 to 6\u2010week intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study demonstrated that IH responded favorably to the treatment of a long\u2010pulse Alexandrite laser while accompany with relatively few complications. The difference between the original untreated and post\u2010treatment scores of all IH and two subgroups were statistically significant, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The difference of the degree of improvement between the two subgroups was not significant (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). It was observed that IH on the trunk and extremities improved more effectively and more quickly than those on the face, neck, and perineum. Besides, age at the first treatment, the sex of the patients and the presence of proliferation were not significantly correlated with the degree of improvement. Adverse effects were seen in 11 patients (22.91%): blistering (<jats:italic>n<\/jats:italic>\u2009=\u20099), marked edema and erosion without subsequent residual scarring (<jats:italic>n<\/jats:italic>\u2009=\u20091), and hypopigmentation (<jats:italic>n<\/jats:italic>\u2009=\u20091), which improved gradually with time. Fortunately, there was no incidence of scarring or ulceration in this case series of IH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It was clinically effective and safe for early treatment of IH, including the thick\/deep ones, with a long\u2010pulse Alexandrite laser, which indicated be able to reduce the possibility that the IH will reach its full size. In this way it can prevent several complications connected to the rapid proliferation of IH. Lasers Surg. Med. 46:173\u2013179, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22221","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T07:41:18Z","timestamp":1388994078000},"page":"173-179","source":"Crossref","is-referenced-by-count":20,"title":["Beneficial effects of early treatment of infantile hemangiomas with a long\u2010pulse Alexandrite laser"],"prefix":"10.1002","volume":"46","author":[{"given":"Wenting","family":"Su","sequence":"first","affiliation":[{"name":"Department of Dermatology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Wenzhou Children's Hospital Wenzhou 325027 Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhui","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Wenzhou Children's Hospital Wenzhou 325027 Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixin","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Hand and Plastic Surgery The Second Affiliated Hospital of Wenzhou Medical University Wenzhou 325027 Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(86)90109-6"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1986.tb00535.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(99)80041-X"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.200"},{"issue":"4","key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S1064-7406(23)00479-0","article-title":"Vascular anomalies: Classification, diagnosis, and natural history","volume":"9","author":"Marler JJ","year":"2001","journal-title":"Facial Plast Surg Clin North Am"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2010.03.009"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2012.01466.x"},{"issue":"5","key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1001\/jama.1965.03090180047011","article-title":"Cutaneous hemangiomas in children. 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