{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:40:13Z","timestamp":1790030413281,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>To determine the efficacy and safety of a new method for treating acne scarring over a short\u2010term period of 2 months and a long\u2010term period of 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Six faces and 13 shoulders or backs for a total of 19 patients were treated, all of which displayed varying degrees of acne scarring, from moderate to severe. A newly developed high\u2010power unipolar fractional ablative radiofrequency technology was used (iPixel\u2122 RF, Alma Lasers, Caesarea, Israel), with acoustic pressure ultrasound guided dermal injection of the PixelTreat Scars preparation (Alma Lasers), through RF Pixel fractionated microchannels. All patients underwent four treatment sessions at 3\u2010week intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant improvement was observed in scarring, both on the face (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), and on the back and shoulders (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). After 2 months, the percentage of fading on total scarring was 57% on the face and 49% on the back and shoulders; after 6 months, the percentage increased to 62% on the face, and 58% on the back and shoulders, respectively. Patients reported to be Somewhat Satisfied (16%), Satisfied (53%), and Very Satisfied (31%). No unexpected side effects to the ablation and no hypersensitive reactions to PixelTreat Scars were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The bimodal procedure is safe and effective in reducing acne scarring. This represents a new therapeutic alternative of great interest, to be used either as a monotherapy, or in combination with other treatments. Lasers Surg. Med. 46:152\u2013159, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22224","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T08:37:37Z","timestamp":1390984657000},"page":"152-159","source":"Crossref","is-referenced-by-count":23,"title":["Attenuation of acne scars using high power fractional ablative unipolar radiofrequency and ultrasound for transepidermal delivery of bioactive compounds through microchannels"],"prefix":"10.1002","volume":"46","author":[{"given":"Mario A.","family":"Trelles","sequence":"first","affiliation":[{"name":"Instituto M\u00e9dico Vilafortuny Cambrils Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A.","family":"Mart\u00ednez\u2010Carpio","sequence":"additional","affiliation":[{"name":"Clinical Research Unit IMC\u2010Investil\u00e1ser Sabadell Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/893080"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4103\/0974-2077.69021","article-title":"Novel technology in the treatment of acne scars: The matrix\u2010tunable radiofrequency technology","volume":"3","author":"Ramesh M","year":"2010","journal-title":"J Cutan Aesthet Surg"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.687824"},{"key":"e_1_2_5_5_1","first-page":"18","article-title":"Treatment of acne scars of skin types II to V by sublative fractional bipolar radiofrequency and bipolar radiofrequency combined with diode laser","volume":"4","author":"Taub AF","year":"2011","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12103"},{"key":"e_1_2_5_7_1","first-page":"674","article-title":"Easy Dressing\u201d: An economical, transparent nonporous film for wound care after laser resurfacing","volume":"137","author":"Trelles MA","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22175"},{"key":"e_1_2_5_9_1","first-page":"39","article-title":"New\u2010generation radiofrequency technology","volume":"91","author":"Krueger N","year":"2013","journal-title":"Cutis"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.738916"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22105"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05704.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-013-0176-3"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2013.854632"},{"key":"e_1_2_5_15_1","first-page":"1189","article-title":"Comparison of Q\u2010switched 1064\u2009nm Nd:YAG laser and fractional CO2 laser efficacies on improvement of atrophic facial acne scars","volume":"16","author":"Asilian A","year":"2011","journal-title":"J Res Med Sci"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103\u2010013\u20101372\u20108"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22224","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.22224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:03:26Z","timestamp":1716491006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.22224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,29]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1002\/lsm.22224"],"URL":"https:\/\/doi.org\/10.1002\/lsm.22224","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,29]]}}}