{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:44:23Z","timestamp":1780922663991,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>As the demand for diminished procedure\u2010associated downtime continues to increase, nonablative fractional laser resurfacing is becoming a more popular intervention in the progression of photoaging. Patients with pigmented skin and a mild degree of photodamage may be particularly suited for a less intensive laser treatment. In this study, we have evaluated the safety and efficacy of a low energy, low density 1,440\u2010nm fractional laser in the treatment of multiple signs of photoaging including dyspigmentation, wrinkling, tissue laxity, enlarged pores, and skin roughness in Asians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Ten Chinese subjects with Fitzpatrick skin types III\u2013V and visible signs of photodamage participated in this study. Patients received four treatments at 2\u2010week intervals with a 1,440\u2010nm diode\u2010based fractional laser. Photographs were taken at baseline, 2 weeks after each of the first three treatments and 4 weeks after the final treatment. Images were evaluated independently by two physicians. Clinical improvement and adverse events were analyzed. Discomfort, heat sensation and overall patient satisfaction associated with the procedure were also quantified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this prospective single\u2010arm study, signs of photoaging were examined after treatment with the 1,440\u2010nm laser. Here we show that a series of four treatments with this device produced a mild improvement in skin texture, pigmentation, and wrinkling. Changes in pore size and skin laxity failed to reach statistical significance. Immediate after\u2010effects of the procedure included erythema and edema which were transient and left no permanent sequela. A significant proportion of patients reported some degree of discomfort during the procedure despite use of a topical anesthetic. One patient developed a discrete, localized area of post\u2010inflammatory hyperpigmentation which completely resolved by the final follow up visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The low energy, low density nonablative 1,440\u2010nm fractional laser produces a mild improvement in select signs of photodamage after four treatments without any long\u2010term adverse effects. Lasers Surg. Med. 46:375\u2013379, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22242","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T09:56:46Z","timestamp":1394791006000},"page":"375-379","source":"Crossref","is-referenced-by-count":23,"title":["Evaluating the safety and efficacy of the 1,440\u2010nm laser in the treatment of photodamage in Asian skin"],"prefix":"10.1002","volume":"46","author":[{"given":"Shoshana","family":"Marmon","sequence":"first","affiliation":[{"name":"Hong Kong Dermatology and Laser Centre Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha Y. N.","family":"Shek","sequence":"additional","affiliation":[{"name":"Hong Kong Dermatology and Laser Centre Hong Kong China"},{"name":"Division of Dermatology, Department of Medicine University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.K.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Hong Kong Dermatology and Laser Centre Hong Kong China"},{"name":"Division of Dermatology, Department of Medicine University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola P.Y.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny CY","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry H.L.","family":"Chan","sequence":"additional","affiliation":[{"name":"Hong Kong Dermatology and Laser Centre Hong Kong China"},{"name":"Division of Dermatology, Department of Medicine University of Hong Kong Hong Kong China"},{"name":"Wellman Center for Photomedicine Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20976"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.01.002"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1329413"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20048"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.08.041"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20512"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20484"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200910030-00002"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.19858"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.06.006"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1998.tb04161.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01258.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20974"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.41643"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.738909"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328249"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22242","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Flsm.22242","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.22242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T10:05:33Z","timestamp":1696500333000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.22242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,14]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1002\/lsm.22242"],"URL":"https:\/\/doi.org\/10.1002\/lsm.22242","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,14]]}}}