{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:16:05Z","timestamp":1792656965685,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Low level laser (light) therapy (LLLT) has been demonstrated to promote hair growth in males. A double\u2010blind randomized controlled trial was undertaken to define the safety and physiologic effects of LLLT on females with androgenic alopecia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010seven females (18\u201360 years old, Fitzpatrick I\u2013IV, and Ludwig\u2013Savin Baldness Scale I\u20102, I\u20103, I\u20104, II\u20101, II\u20102 baldness patterns) were recruited. A transition zone scalp site was selected; hairs were trimmed to 3\u2009mm height; the area was tattooed and photographed. The active group received a \u201cTOPHAT655\u201d unit containing 21, 5\u2009mW diode lasers (655\u2009\u00b1\u20095\u2009nm) and 30 LEDS (655\u2009\u00b1\u200920\u2009nm), in a bicycle\u2010helmet like apparatus. The placebo group unit appeared identical, containing incandescent red lights. Patients treated at home every other day\u2009\u00d7\u200916 weeks (60 treatments, 67\u2009J\/cm<jats:sup>2<\/jats:sup> irradiance\/25\u2009minute treatment, 2.9\u2009J dose), with follow up and photography at 16 weeks. A masked 2.85\u2009cm<jats:sup>2<\/jats:sup> photographic area was evaluated by another blinded investigator. The primary endpoint was the percent increase in hair counts from baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two patients completed the study (24 active, 18 sham). No adverse events or side effects were reported. Baseline hair counts were 228.2\u2009\u00b1\u2009133.4 (<jats:italic>N<\/jats:italic>\u2009=\u200918) in the sham and 209.6\u2009\u00b1\u2009118.5 (<jats:italic>N<\/jats:italic>\u2009=\u200924) in the active group (<jats:italic>P<\/jats:italic>\u2009=\u20090.642). Post Treatment hair counts were 252.1\u2009\u00b1\u2009143.3 (N\u2009=\u200918) in the sham group and 309.9\u2009\u00b1\u2009166.6 (<jats:italic>N<\/jats:italic>\u2009=\u200924) in the active group (<jats:italic>P<\/jats:italic>\u2009=\u20090.235). The change in hair counts over baseline was 23.9\u2009\u00b1\u200930.1 (<jats:italic>N<\/jats:italic>\u2009=\u200918) in the sham group and 100.3\u2009\u00b1\u200953.4 (<jats:italic>N<\/jats:italic>\u2009=\u200924) in the active group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). The percent hair increase over the duration of the study was 11.05\u2009\u00b1\u200948.30 (<jats:italic>N<\/jats:italic>\u2009=\u200918) for the sham group and 48.07\u2009\u00b1\u200917.61 (<jats:italic>N<\/jats:italic>\u2009=\u200924) for the active group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). This demonstrates a 37% increase in hair growth in the active treatment group as compared to the placebo group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LLLT of the scalp at 655\u2009nm significantly improved hair counts in women with androgenetic alopecia at a rate similar to that observed in males using the same parameters. Lasers Surg. Med. 46:601\u2013607, 2014. \u00a9 2014 The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22277","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T21:36:26Z","timestamp":1407965786000},"page":"601-607","source":"Crossref","is-referenced-by-count":106,"title":["The growth of human scalp hair in females using visible red light laser and LED sources"],"prefix":"10.1002","volume":"46","author":[{"given":"Raymond J.","family":"Lanzafame","sequence":"first","affiliation":[{"name":"Raymond J. Lanzafame MD PLLC 757 Titus Avenue 14617 Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond R.","family":"Blanche","sequence":"additional","affiliation":[{"name":"NST Consulting LLC 641 Shunpike Rd #311 07928 Chatham New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Chiacchierini","sequence":"additional","affiliation":[{"name":"R.P. Chiacchierini &amp; Associates 15825 Shady Grove Road (Suite 30) 20850 Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Kazmirek","sequence":"additional","affiliation":[{"name":"Kaz Arts Photography 701 Foothill Rd 08807 Bridgewater New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Sklar","sequence":"additional","affiliation":[{"name":"Center for Aesthetic Dermatology 800 Woodbury Road 11797 Woodbury New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,13]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"621","article-title":"Die Wirkung der Laserstrahlen auf den Haarwwuchs der Maus","volume":"9","author":"Mester E","year":"1967","journal-title":"Rad Biol Ther;"},{"key":"e_1_2_7_3_1","first-page":"628","article-title":"Effect of laser on hair growth in mice","volume":"19","author":"Mester E","year":"1967","journal-title":"Kiserl Orvostud"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31168"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2006.00269.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20485"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170601134479"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170902842531"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764171003674448"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32092.x"},{"key":"e_1_2_7_11_1","first-page":"1","article-title":"The effect of low\u2010power laser on the murine hair growth","volume":"31","author":"Chung PS","year":"2004","journal-title":"J Korean Soc Plastic Reconstruct Surg"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200929050-00001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01968.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000265678"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/153082003769591209"},{"key":"e_1_2_7_16_1","first-page":"15","article-title":"Tratamiento de la alopecia areata con laser HeNe","volume":"1","author":"Trelles MA","year":"1984","journal-title":"Investigacion Y Clinica Laser"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22173"},{"key":"e_1_2_7_18_1","unstructured":"http:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf12\/k122248.pdfaccessed 5\/1\/14."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22170"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(84)80577-3"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1997.tb03239.x"},{"key":"e_1_2_7_22_1","first-page":"14","article-title":"The science of low power laser therapy","author":"Karu TI","year":"1998","journal-title":"London Gordon and Breach Sci. 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