{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T13:53:23Z","timestamp":1726149203739},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T00:00:00Z","timestamp":1421020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swiss National Funding Grant","award":["320030-135197"],"award-info":[{"award-number":["320030-135197"]}]},{"name":"Swiss Society of Surgery Grant for Clinical Researchers"},{"name":"UNIL FBM Grant for MD-PhDs"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The pre\u2010conditioning of tumor vessels by low\u2010dose photodynamic therapy (L\u2010PDT) was shown to enhance the distribution of chemotherapy in different tumor types. However, how light dose affects drug distribution and tumor response is unknown. Here we determined the effect of L\u2010PDT fluence on vascular transport in human mesothelioma xenografts. The best L\u2010PDT conditions regarding drug transport were then combined with Lipoplatin<jats:sup>\u00ae<\/jats:sup> to determine tumor response. <jats:italic>in vivo<\/jats:italic>. Lasers Surg. Med. 47:323\u2013330, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nude mice bearing dorsal skinfold chambers were implanted with H\u2010Meso1 cells. Tumors were treated by Visudyne<jats:sup>\u00ae<\/jats:sup>\u2010mediated photodynamic therapy with 100\u2009mW\/cm<jats:sup>2<\/jats:sup> fluence rate and a variable fluence (5, 10, 30, and 50\u2009J\/cm<jats:sup>2<\/jats:sup>). FITC\u2010Dextran (FITC\u2010D) distribution was assessed in real time in tumor and normal tissues. Tumor response was then determined with best L\u2010PDT conditions combined to Lipoplatin<jats:sup>\u00ae<\/jats:sup> and compared to controls in luciferase expressing H\u2010Meso1 tumors by size and whole body bioluminescence assessment (n\u2009=\u20097\/group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tumor uptake of FITC\u2010D following L\u2010PDT was significantly enhanced by 10\u2010fold in the 10\u2009J\/cm<jats:sup>2<\/jats:sup> but not in the 5, 30, and 50\u2009J\/cm<jats:sup>2<\/jats:sup> groups compared to controls. Normal surrounding tissue uptake of FITC\u2010D following L\u2010PDT was significantly enhanced in the 30\u2009J\/cm<jats:sup>2<\/jats:sup> and 50\u2009J\/cm<jats:sup>2<\/jats:sup> groups compared to controls. Altogether, the FITC\u2010D tumor to normal tissue ratio was significantly higher in the 10\u2009J\/cm<jats:sup>2<\/jats:sup> group compared others. Tumor growth was significantly delayed in animals treated by 10\u2009J\/cm2\u2010L\u2010PDT combined to Lipoplatin<jats:sup>\u00ae<\/jats:sup> compared to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fluence of L\u2010PDT is critical for the optimal distribution and effect of subsequently administered chemotherapy. These findings have an importance for the clinical translation of the vascular L\u2010PDT concept in the clinics. Lasers Surg. Med. 47:323\u2013330, 2015. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.22329","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T01:17:57Z","timestamp":1421111877000},"page":"323-330","source":"Crossref","is-referenced-by-count":8,"title":["Fluence plays a critical role on the subsequent distribution of chemotherapy and tumor growth delay in murine mesothelioma xenografts pre\u2010treated by photodynamic therapy"],"prefix":"10.1002","volume":"47","author":[{"given":"Yabo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thoracic and Vascular Surgery Centre Hospitalier Universitaire Vaudois Ecole Polytechnique Federale de Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Vascular Surgery Centre Hospitalier Universitaire Vaudois Ecole Polytechnique Federale de Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Aude","family":"Le Bitoux","sequence":"additional","affiliation":[{"name":"Department of Pathology Centre Hospitalier Universitaire Vaudois Ecole Polytechnique Federale de Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Wagnieres","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ecole Polytechnique Federale de Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Vandenbergh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Ecole Polytechnique Federale de Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Vascular Surgery Centre Hospitalier Universitaire Vaudois Ecole Polytechnique Federale de Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Beat","family":"Ris","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Vascular Surgery Centre Hospitalier Universitaire Vaudois Ecole Polytechnique Federale de Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Y","family":"Perentes","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Vascular Surgery Centre Hospitalier Universitaire Vaudois Ecole Polytechnique Federale de Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Krueger","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Vascular Surgery Centre Hospitalier Universitaire Vaudois Ecole Polytechnique Federale de Lausanne Lausanne 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